不同补钙方式对固定献血者血清Ca2+及PTH的影响分析

doi:10.3969/j.issn.1671-2587.2023.06.014

临床输血与检验 ›› 2023, Vol. 25 ›› Issue (6): 798-801.DOI: 10.3969/j.issn.1671-2587.2023.06.014

不同补钙方式对固定献血者血清Ca²⁺及PTH的影响分析

李丽, 刘晓庆, 孙玉艾, 李松芯

天津市血液中心,天津 300110

收稿日期:2023-08-18 出版日期:2023-12-20 发布日期:2024-01-15
作者简介:李丽,主要从事成分血采集和质量控制方面研究,（E-mail）994866900@qq.com。

Analysis of the Influence of Different Calcium Supplementation Methods on Blood Ca²⁺ and PTH in Fixed Blood Donors

LI Li, LIU Xiaoqing, SUN Yuai, et al

Tianjin Blood Center,Tianjin 300110

Received:2023-08-18 Online:2023-12-20 Published:2024-01-15

摘要/Abstract

摘要： 目的探讨不服钙剂、口服葡萄糖酸钙、口服乳酸钙颗粒三种情况对于固定单采血小板献血者血清钙（Ca²⁺）、血清甲状旁腺素（PTH）和献血不良反应的影响,比较哪种钙剂的效果更好。方法 2020年7月—9月从本中心固定献血者人群中招募35名志愿者（男性21名,女性14名）共同参与三组实验：第一组实验为对照组,即在单采血小板前不予补充钙剂;第二组在采前20 min（采样后）补充10%葡萄糖酸钙口服液;第三组在采前20 min（采样后）补充乳酸钙颗粒。三组实验中,每一组都分别在采样时（采前20 min）、穿刺时（采集0 min）、采集初中期（采集20 min）、采集中后期（采集40 min）留取全血标本5 mL用于血清Ca²⁺和血清PTH的检测。比较三组血清Ca²⁺和血清PTH数值的变化趋势,探讨钙剂的作用效果。结果献血者血清Ca²⁺随时间的改变在显著变化（F=101.979,P<0.001）,组间效应不显著（F=0.059,P=0.943>0.05）;血清PTH随时间的改变在显著变化（F=495.834,P<0.001）,组间效应不显著（F=1.241,P=0.294>0.05）;血清Ca²⁺和血清PTH数值随采血时间的变化成负相关。两种钙剂均能减少枸橼酸盐反应的发生概率（P<0.001）。结论无论是否预防性补充钙剂,或是补充何种钙剂,献血者体内血清Ca²⁺均能够在PTH的作用下保持稳定;预防性补充钙剂可以降低枸橼酸盐反应发生率。

关键词: 单采血小板, 钙剂, 血清钙, 甲状旁腺素, 枸橼酸盐反应

Abstract: Objective To explore the effects of three conditions of not taking calcium, taking calcium gluconate orally, and taking calcium lactate granules orally on blood Ca²⁺, PTH and adverse reactions of blood donors with fixed platelets donors, and to compare which calcium is better. Methods From July to September 2020, 35 volunteers (20 males and 15 females) were recruited from the fixed blood donor population at our center to participate in three sets of trials:The first group of experiments was a control group, which did not supplement calcium before platelet collection;The second group was supplemented with 10% Calcium gluconate oral liquid 20 minutes before collection (after sampling);The third group supplemented calcium lactate granules 20 minutes before harvest (after sampling).In each of the three experiments, 5ml of whole blood samples were collected for the detection of blood Ca²⁺ and PTH at sampling time (20 minutes before collection), needle insertion time (0 minutes after collection), middle school stage (20 minutes after collection), and later stage of collection (40 minutes after collection).Compare the trend of changes in blood Ca²⁺ and serum PTH values among three groups, and explore the effect of calcium agents. Results The change in blood Ca²⁺ of donors over time was significant（F=101.979,P<0.001）,the inter group effect was not significant（F=0.059,P=0.943>0.05）; The change in serum PTH over time was significant（F=495.834,P<0.001）,the inter group effect was not significant（F=1.241,P=0.294>0.05）;There was a negative correlation between blood Ca²⁺ and PTH values with changes in blood collection time.Both calcium agents reduce the probability of citric acid reaction.（P<0.05）Conclusion Regardless of whether preventive calcium supplementation was used or what type of calcium supplementation was used, the blood Ca²⁺ in blood donors could remain stable under the action of PTH.Preventive calcium supplements could reduce the risk of citric acid.

Key words: Apheresis Platelets, Calcium, Blood Ca²⁺, PTH, Citrate reaction

中图分类号:

R457

李丽, 刘晓庆, 孙玉艾, 李松芯. 不同补钙方式对固定献血者血清Ca²⁺及PTH的影响分析[J]. 临床输血与检验, 2023, 25(6): 798-801.

LI Li, LIU Xiaoqing, SUN Yuai, et al. Analysis of the Influence of Different Calcium Supplementation Methods on Blood Ca²⁺ and PTH in Fixed Blood Donors[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(6): 798-801.

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不同补钙方式对固定献血者血清Ca²⁺及PTH的影响分析

Analysis of the Influence of Different Calcium Supplementation Methods on Blood Ca²⁺ and PTH in Fixed Blood Donors

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