Abstract: Objective To investigate the variation of the platelet morphology parameters before blood donation and its impact on the production of the single donor platelet. Methods According to the quality inspection result ,24 cases of platelet collections from January 2007 to December 2014 produced less than 2.5 ×10¹⁰/ bag, and 344 cases over 2.5 ×10¹¹/ bag. These samples were divided into two groups according to the separatrix of 2.5×10¹¹/ bag and analyzed for the difference between the two groups of MPV and PDW before blood donation and the platelet production. Results The difference between the two groups in MPV and PDW over or below 2.5×10¹¹/bag was statistically significant before blood donation; while no obvious difference was noted between MPV and PDW in the same group. Conclusion Blood platelet morphology variation before blood donation affects platelet production of collection. The plateletcollection efficiency may decrease in the blood donor with MPV>9.085 5 fl or PDW > 12.575 6% before blood donation, an appropriate large volum of whole blood might be collected, or the blood donation should be postponed.

Key words: Platelet morphology, Reference value, Single donor platelets