Abstract: Objective To provide evidence for recruiting blood donors in low-risk population and ensure the safety of blood transfusion，we analyzed the status of human immunodeficiency virus （ HIV ） infection among unpaid blood donors in Bozhou area. Methods A total of 200 463 blood donors were selected from 2010 to 2017 in Bozhou area. According to the results of the confirmatory test conducted by Bozhou center for disease control and prevention，the blood donors with positive results of HIV confirmatory test were divided into groups according to the year，sex，educational background，age，blood donation types and blood donation frequency. Results 35 cases of HIV infection were found in 200 463 blood donors，the infection rate was 17.46/100 000. The infection rate of male blood donors was 28.16/100 000 （82.86%），and that of female blood donors was 6.15/100 000（17.14%）. The infection rate of blood donors with associate degree or above was 9.22/100 000（8.57%），and that of blood donors with high school degree or below was 19.06/100 000 （91.43%）.The infection rate of blood donors aged 18 - 35 years was 21.56/100 000 （60%），that of blood donors aged 36-45 years was 15.53 / 100 000（31.43%），and that of blood donors aged 46-60 years was 9.32/100 000（8.57%）. The infection rate of whole blood donors was 17.92/100 000（100%）. The infection rate of primary blood donors was 36.98/100，000 （60%），that of repeated blood donors was 14.20/100 000，and that of fixed blood donors was 3.38/100 000. Conclusion Voluntary blood donors infected with HIV in Bozhou area have certain characteristics of gender，educational background and age distribution. It is necessary to strengthen the publicity and popularization of voluntary blood donation knowledge，adhere to the principle of recruiting blood donors from low-risk population，select more sensitive reagents and choose more sensitive virus nucleic acid amplification detection （NAT） method，to further ensure the safety of blood transfusion.

Key words: Blood donation , Infection, HIV