Abstract: Objective To prevent the HIV transmission through blood,and ensure the blood safety in clinics,we studied the status of HIV infection in blood donors in Nanjing. Methods The retrospective analysis of epidemiological characteristics of voluntary non-remunerated blood donors with HIV infection were carried out from 2012 to 2016 in Nanjing. Results Among 398 807 volunteer blood donors from 2012 to 2016,93 donors were HIV infection and the positive rate was 0.23‰. By chi-square test and trend test analysis,the difference in years was statistically significant（P<0.05）.The difference of change trend in five years has no statistical significance（P>0.05）. The difference in age,gender,occupation between the groups was statistically significant（P<0.05）,the difference in eduacation level between the groups has no statistically significance（P>0.05）. Conclusions Multiple measures should be taken to Ereduce the risk of blood infection with HIV virus,such as,emphasis of consulting work before every blood donationrecruitment of blood donors from lower risk groups,and carrying out comprehensively blood nucleic acid detection to reduce input "window period".

Key words: HIV, Voluntary blood donors, Blood detection