Abstract: Objective To investigate the influences of ABO blood group,gender and age on factor Ⅷ and fibrinogen in the plasma component. Methods The cryoprecipitated antihemophilic factors and cryoprecipitate reduced plasma were prepared by centrifugal method. ABO blood group of blood donors,factor Ⅷ activities and fibrinogen levels in the cryoprecipitated antihemophilic factors and cryoprecipitate reduced plasma were detected,and the data were compared and analyzed by t test,LSD method and multiple linear stepwise regression analysis. Results The level of FⅧ in group A and group B from cryoprecipitated antihemophilic factor was significantly higher than that in group O （P<0.001）. The level of FⅧ in group A and group O from cryoprecipitate reduced plasma was significantly lower than that in group B （P <0.01）.The level of FIB in the female group from cryoprecipitated antihemophilic factor was higher than that in the male group（P<0.005）.The level of FIB in the female group from cryoprecipitate reduced plasma was higher than that in the male group（P<0.05）.The level of FⅧ in the >30 year olds group from cryoprecipitate reduced plasma was significantly higher than that in the≤30 year olds group （P<0.05）.The level of FIB in the >30 year olds group from cryoprecipitate reduced plasma was significantly higher than that in the≤30 year olds group （P<0.001）. Conclusion Blood group is the factor affecting the FⅧ level of both cryoprecipitated antihemophilic factor and cryoprecipitate reduced plasma,and the content in group B is the highest. The ABO blood group has no effect on the FIB levels in either cryoprecipitated antihemophilic factor or cryoprecipitate reduced plasma.Gender is the factors affecting the FⅧ and FIB level of cryoprecipitated antihemophilic factor,it was also an influencing factor of the level of FIB in cryoprecipitate reduced plasma,and the female group is higher than the male group. Age is the factor affecting the FⅧ and FIB levels in cryoprecipitate reduced plasma.Which are significantly higher among blood donors in the >30 year olds group than that in the≤30 year olds group.

Key words: Cryoprecipitated antihemophilic factor, Cryoprecipitate reduced plasma, Factor Ⅷ, Fibrinogen, Blood group, Gender, Age