[1] WANG G L,SEMENZA G L.Purification and characterization of hypoxia-inducible factor 1[J].J Biol Chem,1995,270(3):1230-1237.
[2] JAAKKOLA P,MOLE D R,TIAN Y M,et al.Targeting of HIF-alpha to the von hippel-lindau ubiquitylation complex by O2-Regulated prolyl hydroxylation[J].Science,2001,292(5516):468-472.
[3] WU D,RASTINEJAD F.Structural characterization of mammalian bHLH-PAS transcription factors[J].Curr Opin Struct Biol,2017,43:1-9.
[4] SCHEUERMANN T H,LI Q M,MA H W,et al.Allosteric inhibition of hypoxia inducible factor-2 with small molecules[J].Nat Chem Biol,2013,9(4):271-276.
[5] KAELIN W G JR,RATCLIFFE P J JR.Oxygen sensing by metazoans:the central role of the HIF hydroxylase pathway[J].Mol Cell,2008,30(4):393-402.
[6] PENG J,ZHANG L,DRYSDALE L,et al.The transcription factor EPAS-1/hypoxia-inducible factor 2alpha plays an important role in vascular remodeling[J].PNAS,2000,97(15):8386-8391.
[7] COMPERNOLLE V,BRUSSELMANS K,ACKER T,et al.Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation,whereas treatment with VEGF prevents fatal respiratory distress in premature mice[J].Nat Med,2002,8(7):702-710.
[8] GERRI C,MARASS M,ROSSI A,et al.Hif-1α and Hif-2α regulate hemogenic endothelium and hematopoietic stem cell formation in zebrafish[J].Blood,2018,131(9):963-973.
[9] ROUAULT-PIERRE K,LOPEZ-ONIEVA L,FOSTER K,et al.HIF-2α protects human hematopoietic stem/progenitors and acute myeloid leukemic cells from apoptosis induced by endoplasmic Reticulum stress[J].Cell Stem Cell,2013,13(5):549-563.
[10] LEE S Y,PARK K H,YU H G,et al.Controlling hypoxia-inducible factor-2α is critical for maintaining bone homeostasis in mice[J].Bone Res,2019,7(1):1-14.
[11] YAMASHITA T,OHNEDA O,SAKIYAMA A,et al.The microenvironment for erythropoiesis is regulated by HIF-2α through VCAM-1 in endothelial cells[J].Blood,2008,112(4):1482-1492.
[12] GUARNERIO J,COLTELLA N,ALA U,et al.Bone marrow endosteal mesenchymal progenitors depend on HIF factors for maintenance and regulation of hematopoiesis[J].Stem Cell Rep,2014,2(6):794-809.
[13] HSU T S,LIN Y L,WANG Y,et al.HIF-2α is indispensable for regulatory T cell function[J].Nat Commun,2020,11(1):1-16.
[14] KAPITSINOU P P,LIU Q D,UNGER T L,et al.Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal Anemia[J].Blood,2010,116(16):3039-3048.
[15] IMERI F,NOLAN K A,BAPST A M,et al.Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics,cell autonomous feedback regulation,and a telocyte phenotype[J].Kidney Int,2019,95(2):375-387.
[16] RANKIN E B,BIJU M P,LIU Q,et al.Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo[J].J Clin Invest,2007,117(4):1068-1077.
[17] PERCY M J,ZHAO Q,FLORES A,et al.A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis[J].PNAS,2006,103(3):654-659.
[18] SU J,LI Z Q,CUI S,et al.The local HIF-2α/EPO pathway in the bone marrow is associated with excessive erythrocytosis and the increase in bone marrow microvessel density in chronic mountain sickness[J].High Alt Med Biol,2015,16(4):318-330.
[19] DEL BALZO U,SIGNORE P E,Walkinshaw G,et al.Nonclinical characterization of the hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat,a novel treatment of Anemia of chronic kidney disease[J].J Pharmacol Exp Ther,2020,374(2):342-353.
[20] WANG K P,WU J,XU J Y,et al.Correction of Anemia in chronic kidney disease with Angelica sinensis polysaccharide via restoring EPO production and improving iron availability[J].Front Pharmacol,2018,9:803.
[21] KAPITSINOU P P,LIU Q D,UNGER T L,et al.Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal Anemia[J].Blood,2010,116(16):3039-3048.
[22] SCHWARTZ A J,DAS N K,RAMAKRISHNAN S K,et al.Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload[J].J Clin Investig,2019,129(1):336-348.
[23] ANDERSON S A,NIZZI C P,CHANG Y I,et al.The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption[J].Cell Metab,2013,17(2):282-290.
[24] DAS N,XIE L W,RAMAKRISHNAN S K,et al.Intestine-specific disruption of hypoxia-inducible factor (HIF)-2α improves Anemia in sickle cell disease[J].J Biol Chem,2015,290(39):23523-23527.
[25] RENASSIA C,PEYSSONNAUX C.New insights into the links between hypoxia and iron homeostasis[J].Curr Opin Hematol,2019,26(3):125-130.
[26] LEE F S.At the crossroads of oxygen and iron sensing:hepcidin control of HIF-2α[J].J Clin Investig,2019,129(1):72-74.
[27] PASUPNETI S,TIAN W,TU A B,et al.Endothelial HIF-2α as a key endogenous mediator preventing emphysema[J].Am J Respir Crit Care Med,2020,202(7):983-995.
[28] CHAURASIA S N,KUSHWAHA G,KULKARNI P P,et al.Platelet HIF-2α promotes thrombogenicity through PAI-1 synthesis and extracellular vesicle release[J].Haematologica,2019,104(12):2482-2492.
[29] SCHÖDEL J,GRAMPP S,MAHER E R,et al.Hypoxia,hypoxia-inducible transcription factors,and renal cancer[J].Eur Urol,2016,69(4):646-657. |
