Abstract: Objective To explore the application value of idebenone in platelet preservation through its effect of on platelet biological characteristics. Methods In vitro experiment, platelet-rich plasma was added idebenone with the final concentration of 10 μg/mL as the experimental group. We detected the platelet adhesion and aggregation function, plasma malondialdehyde (MDA) concentration, reduced glutathione (GSH) concentration, and CD62p expression on platelet membrane surface and JC-1 on mitochondrion surface. Results Compared with the control group, platelet adhesion and aggregation rate decreased to a certain extent（P<0.05）; The MDA level decreased（P<0.05）while reduced GSH level increased（P<0.05）; The positive rate of CD62p showed no significant change, but the positive rate of JC-1 increased significantly（P<0.05）. Conclusion Idebenone would be beneficial to the metabolism of platelet mitochondria, but it has a certain inhibitory effect on platelet adhesion and aggregation with the concentration of 10 μg/mL.

Key words: Idebenone, Platelet, Adhesion, Aggregation, CD62p