Abstract: The big data of unexpected red blood cell antibody and Rh blood group distribution in Chinese population shows that the proportion of anti-RhCE antibody (41.94%) is 4.7 times higher than that of anti-RhD antibody (8.93%) among unexpected antibodies in hospitalized patients. In random blood transfusion, the probability of RhCE antigen mismatch (25.16%) is 51.4 times higher than that of RhD antigen mismatch (0.49%). These data indicate that RhCE antigen mismatch is the main risk for Chinese transfusion patients, and establishing RhCE antigen matching transfusion strategies suitable for Chinese patients is crucial for transfusion safety.

Key words: Unexpected red blood cell antibody, Rh blood group, Rh alloantibody, RhCE antigen matching, Precise transfusion, Transfusison safety