Identification of Weak D Type 15 of Rh Blood Group System

doi:10.3969/j.issn.1671-2587.2016.05.003

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2016, Vol. 18 ›› Issue (5): 416-419.DOI: 10.3969/j.issn.1671-2587.2016.05.003

• Original Articles • Previous Articles Next Articles

Identification of Weak D Type 15 of Rh Blood Group System

CHEN Qing, LI Ping, LU Le, et al

Jiangsu Province Blood Center,Nanjing 210042

Received:2016-03-11 Online:2016-10-20 Published:2017-05-19

Abstract

Abstract: ObjectiveBy studying two patients who displayed different serological phenotypes in Rh variants, the author aimed to give suggestions to safe transfusion for individuals with Rh variants. Methods The Rh(D) negative patients screened by IgM type anti-D antibody were enrolled precedent. The variants were determined by three different sources of IgG type anti-D antibodies. The genetic mutation locus was analyzed by molecular assay. Results The two patients with Rh variants showed different results of serological tests. However, the results of RHD gene mutation analysis demonstrated that both patients were weak D type 15 of Rh blood group. Conclusion The two patients with weak D type 15 of Rh(D) antigen in this study were the most common type in the Han nationality. These findings indicated that Rh(D) variants should be analyzed by molecular assays for the sake of safe transfusion.

Key words: Rh blood group, Weak D type 15, Genotyping

CLC Number:

R457.1

CHEN Qing, LI Ping, LU Le, et al. Identification of Weak D Type 15 of Rh Blood Group System[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2016, 18(5): 416-419.

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Identification of Weak D Type 15 of Rh Blood Group System

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