Abstract: Objective To investigate the effect of heparin-binding protein (HBP) and procalcitonin (PCT ) in the diagnosis of pediatric respiratory bacterial infection. Methods From January 2016 to June 2018 pediatric with infectious diseases were treated in our hospital, among them 45 children with respiratory bacterial infection, 39 cases children with Non-bacterial infection of the respiratory tract at the same time, 40 children with non-infections.The levels of serum HBP and PCT in each group were detected. Results HBP and PCT of pediatric respiratory bacterial infection group were significantly higher than that of Non-bacterial infection and non-infection group.When the cut-off value of HBP was 13.78 ng/ml, the diagnostic sensitivity and specificity were 87.46% and 94.42%.When the cut-off value of PCT was 0.13ng/ml, the diagnostic sensitivity and specificity were 71.23％ and 85.69%.The sensitivity and specificity of HBP and PCT in the combined diagnosis of pediatric respiratory bacterial infection were 92.67% and 94.42%. Conclusion The combined detection of HBP and PCT has gooddiagnostic value in the diagnosis of pediatric respiratory bacterial infection, which is worthy of clinical use．

Key words: Procalcitonin, Heparin-binding protein, Infectious disease