Abstract: Objective To explore the value of serum amyloid A (SAA), creatine kinase (CK) and endothelin (ET) levels for assessing the severity of acute infective diarrhea in children. Methods From February 2017 to November 2018, 173 children with acute infectious diarrhea were set up as observation group. The serum SAA, CK and ET levels were compared in observation group. Results Before treatment, SAA, CK, ET levels in children with different illness severity were significantly different, severe group>medium group>light group（P<0.05）. SAA, CK and ET levels were positively associated with the severity of acute infectious diarrhea in children（r=5.320,P=0.007;r=4.419,P=0.034;r=5.852,P=0.016). After treatment, the levels of markers were lower than those before treatment in observation group（P<0.05）. Conclusion Serum SAA, CK and ET levels are of great significance in evaluation of the severity of acute infectious diarrhea in children, and can be used as markers to assist in assessing the severity of acute infectious diarrhea in children.

Key words: Serum amyloid A, Creatine kinase, Endothelin, Children, Acute infective diarrhea