Abstract: Objective To investigate how donor blood type, gender, age, and their interactions influence the levels of Factor Ⅷ (FⅧ) in cryoprecipitate and fresh frozen plasma (FFP), as well as the rate of product qualified. This study aims to provide scientific evidence for improving blood product quality monitoring and optimizing clinical transfusion strategies. Methods A retrospective analysis was conducted on quality monitoring data for 456 bags of cryoprecipitate and 128 bags of FFP collected at our institute from 2022 to 2023. Data were analyzed using chi-square tests, independent sample t-tests, ANOVA, LSD tests, and multiple linear and binary logistic regression analyses. Results The unqualified rate of FⅧ in cryoprecipitate and FFP was significantly higher than in other quality control items. In cryoprecipitate, the FⅧ level was the highest in AB blood type and the lowest in O blood type. Similarly, in FFP, O blood type had the lowest FⅧ levels. The FⅧ level in cryoprecipitate was the lowest in the younger age group and the highest in the elderly groups. In FFP, the FⅧ level in the younger age group was significantly lower than in the middle-aged and elderly groups. Both blood type and age independently affected FⅧ levels in cryoprecipitate and FFP, while the interactions between blood type, gender, and age showed no significant impact. AB blood type and increasing age positively influenced FⅧ levels in cryoprecipitate, whereas O blood type had a negative impact. Similarly, in FFP, O blood type negatively affected FⅧ levels, while the middle-aged and elderly groups had a positive impact. Additionally, O blood type was significantly associated with a higher risk of non-conformance in both cryoprecipitate and FFP. Conclusion The unqualified rate for FⅧ levels is the highest among quality control items for cryoprecipitate and FFP. Blood type and age are key factors influencing FⅧ levels, with O blood type significantly increasing the risk of unqualified FⅧ in both cryoprecipitate and FFP.

Key words: Cryoprecipitate, Fresh frozen plasma, Coagulation factor Ⅷ, Quality control, Blood donor characteristics