• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)
临床输血与检验

临床输血与检验 ›› 2017, Vol. 19 ›› Issue (6): 592-595.DOI: 10.3969/j.issn.1671-2587.2017.06.018

• 临床检验 • 上一篇    下一篇

山莨菪碱注射液联合阿奇霉素序贯治疗支原体肺炎患儿的疗效*

徐康, 李钊, 王小象, 施益农   

  1. 225400 江苏省泰兴市人民医院儿科（徐康,李钊,王小象）;
    第二中医院儿科（施益农）
  • 收稿日期:2017-04-23 出版日期:2017-12-20 发布日期:2017-12-13
  • 作者简介:徐康（1972-）,男,江苏泰兴人,副主任医师,学士,主要从事小儿内科病的治疗工作,（Tel）13376030899（E-mail）cjfytxz@163.com。
  • 基金资助:
    *本课题受江苏省卫生厅科研课题基金支持项目（No; LZ13098）资助

A Therapeutic Effect of Anisodamine Combined with Azithromycin Sequential Administration on Children with Mycoplasma Pneumonia

XU Kang, LI Zhao, WANG Xiao-xiang et al   

  1. Department of Pediatrics,Taixing Hospital,Jiangsu 225400
  • Received:2017-04-23 Online:2017-12-20 Published:2017-12-13

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摘要： 目的 探讨山莨菪碱注射液联合阿奇霉素序贯疗法治疗支原体肺炎患儿的临床疗效,及对血清免疫学指标的影响。方法 选择2015年2月~2017年2月本院收治的支原体肺炎患儿80例,按随机数字表分为2组,每组40例。对照组仅给予阿奇霉素治疗,观察组给予山莨菪碱注射液联合阿奇霉素序贯疗法。对比分析两组治疗有效率、治疗后免疫功能和血清免疫学指标水平、临床症状消失时间和住院时间。结果 观察组治疗总有效率优于对照组,差异有统计学意义（P<0.05）;观察组治疗后IgA、IgM、IgG水平均高于对照组,差异有统计学意义（P<0.05）;观察组治疗后CCSP水平高于对照组,MCP-4、MDC、CysLTs、sICAM-1、IL-17A水平均低于对照组,差异有统计学意义（P<0.05）;观察组咳嗽消失时间、发热消失时间、喘息消失时间、肺部啰音消失时间和住院时间均短于对照组,差异有统计学意义（P<0.05）。结论 山莨菪碱注射液联合阿奇霉素序贯疗法治疗支原体肺炎患儿可显著提高临床疗效,改善血清免疫学指标,增强机体免疫功能,减轻临床症状,促进早日康复。

关键词: 山莨菪碱注射液, 阿奇霉素, 支原体肺炎, 疗效

Abstract: Objective To investigate the clinical efficacy of anisodamine injection combined with azithromycin sequential therapy for the treatment of Mycoplasma pneumonia and its effect on serum inflammatory and immunological markers.Methods Eighty children infected with M. pneumonia in the hospital were randomly divided into two groups from February 2015 to February 2017. The control group was only given azithromycin,the observation group was given anisodamine injection combined with azithromycin sequential therapy. The effective rate of clinical treatment,serum cytokines and immunological indexes,the disappearance of clinical symptoms and signs,and the duration of hospitalization were compared and analyzed. Results The total effective rate of the observation group was higher than that of the control group （P<0.05）. The levels of IgA,IgM and IgG in the observation group were significantly higher than those in the control group （P<0.05）. MCP-4,MDC,CysLTs,sICAM-1,and IL-17A were found to be decreased significantly in the observation group than those in the control group （P<0.05）. The time of cough appearance in the observation group was earlier than that in the control group. The duration of fever,wheezing,lung rales and the hospitalization was shorter than that of the control group （P<0.05）. Conclusion The anisodamine injection combined with azithromycin sequential therapy in the treatment of Mycoplasma pneumonia infection may improve the clinical curative effect ,decrease the serum inflammatory cytokines and increase immunological markers,resulting in a prompt reduction of the clinical manifestations.

Key words: Anisodamine injection, Azithromycin, Mycoplasma pneumonia, Therapeutic efficacy

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