红细胞贮存损伤的生化和组学变化研究进展*

doi:10.3969/j.issn.1671-2587.2018.06.039

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (6): 672-676.DOI: 10.3969/j.issn.1671-2587.2018.06.039

• 综述 • 上一篇

红细胞贮存损伤的生化和组学变化研究进展^*

孟强, 宋敏, 赵树铭, 范娅涵

400038 重庆,陆军军医大学第一附属医院

收稿日期:2018-07-02 出版日期:2018-12-20 发布日期:2018-11-12
作者简介:孟强（1975-）,男,主管技师,硕士,主要从事血液安全与临床输血研究,（Tel）023-68765483。

Received:2018-07-02 Online:2018-12-20 Published:2018-11-12
Contact: 范娅涵,女,副主任医师,博士,主要从事血液安全与临床输血研究,（Tel）023-68754392。
Supported by:
*本课题受国家自然科学基金（No.81700180）,第三军医大学第一附属医院院管课题（No.SWH2016LHZH-01）资助

摘要/Abstract

摘要： 红细胞贮存损伤一直是RBC体外储存研究所关注的重要问题,涉及到RBC贮存过程中一系列生理、生化、形态和组学成分的改变,这些改变相互作用从而对贮存RBC产生影响。近年来,随着组学技术在输血领域的应用,为RBC贮存损伤提供了新的理解和研究视角,为清除陈旧RBC输血相关的潜在危险因素,寻找和设计新的更加适宜的RBC替代储存策略的发展铺平了道路。

关键词: 红细胞, 贮存损伤, 红细胞凋亡, 输血

中图分类号:

R331.1⁺41R457.1

孟强, 宋敏, 赵树铭, 范娅涵. 红细胞贮存损伤的生化和组学变化研究进展^*[J]. 临床输血与检验, 2018, 20(6): 672-676.

1 Karon B S,Van Buskirk C M,Jaben E A,et al. Temporal sequence of major biochemical events during blood bank storage of packed red blood cells[J]. Blood Transfus,2012,28(4):459-461.
2 李姝,张丽华,苏燕. 代谢组学在红细胞存储损伤研究中的应用[J]. 中国输血杂志,2016,29(12):1413-1415.
3 王全立. 蛋白质组学在输血医学中的运用[J]. 中国输血杂志,2007,20(5):442-446.
4 Mock D M,Widness J A,Veng-Pedersen P,et al. Measurement of post-transfusion red cell survival with the biotin label[J]. Transfusion Med Rev,2014,28(3):114-125.
5 Gevi F,D’Alessandro A,Rinalducci S,et al. Alterations of red blood cell metabolome during cold liquid storage of erythrocyte concentrates in CPD-SAGM[J]. J Proteomics,2012,10(76):168-180.
6 Tsai A G,Hofmann A,Cabrales P,et al. Perfusion vs. oxygen delivery in transfusion with “fresh” and “old” red blood cells: the experimental evidence[J]. TransfusApherSci,2010,43(1):69-78.
7 李蓓,李继明,范丽莉. 洗涤红细胞中K+变化的影响因素研究[J]. 临床检验与输血,2016,18(4):312-315.
8 毛中华,闫沛云,邢志勇. 儿童临床红细胞输血无效分析[J]. 临床检验与输血,2017,19(5):433-435.
9 Antonelou M H,Tzounakas V L,Velentzas A D,et al. Effects of pre-storage leukoreduction on stored red blood cells signaling: a time-course evaluation from shape to proteome[J]. J Proteomics,2012,10(76):220-238.
10 Goodman S R,Daescu O,Kakhniashvili D G,et al. The proteomics and interactomics of human erythrocytes[J]. ExpBiol Med(Maywood),2013,238(5):509-518.
11 Sparrow R L. Time to revisit red blood cell additive solutions and storage conditions: a role for “omics” analyses[J]. Blood Transfus,2012,10(2):s7-11.
12 Kumar P,Maurya P K. L-cysteine efflux in erythrocytes as a function of human age: correlation with reduced glutathione and total anti-oxidant potential[J]. Rejuvenation Res,2013,16(3):179-184.
13 武世文,文爱清. 红细胞储存损伤的研究进展[J]. 中国输血杂志,2013,26(6):593-594.
14 Castagnola M,Messana I,Sanna M T,et al. Oxygen-linked modulation of erythrocyte metabolism:state of the art[J]. Blood Transfus,2010,8(3):s53-58.
15 Lutz H U,Bogdanova A. Mechanisms tagging senescent red blood cells for clearance in healthy humans[J]. Front Physiol,2013,4:387.
16 Barshtein G,Guralb A,Manny N,et al. Storage-induced damage to red blood cell mechanical properties can be only partially reversed by rejuvenation[J]. Transfus Med Hemother,2014,41(3):197-204.
17 Hess J R. Measures of stored red blood cell quality[J]. Vox Sang,2014,107(1):1-9.
18 Tissot J D,Canellini G,Rubin O,et al. Blood microvesicles: from proteomics to physiology[J]. Transl Proteomics,2013,1(1):38-52.
19 王芳. 红细胞制品储存期末溶血率的测定与分析[J]. 临床输血与检验,2016,18(1):26-27.
20 陈书芳,张美萍,张俊平,等. 去白与不去白红细胞悬液洗涤后的质量比较[J]. 临床输血与检验,2016,18(2):160-162.
21 秦艳兰,谭少华,莫海英,等. 去白细胞悬浮红细胞质量分析[J]. 临床输血与检验,2016,18(4):308-311.
22 Sowemimo-Coker S O. Evaluation of an experimental filter designed for improving the quality of red blood cells(RBCs)during storage by simultaneously removing white blood cells and immunomodulators and improving RBC viscoelasticity and Band 3 proteins[J]. Transfusion, 2014,54(3):592-601.
23 Burger P,Hilarius-Stokman P,de Korte D,et al. CD47 functions as a molecular switch for erythrocyte phagocytosis[J]. Blood 2012,119(23):5512-5521.
24 D 'Alessandro A,Mirasole C,Zolla L. Haemoglobin glycation (Hb1Ac) increases during red blood cell storage: a MALDI-TOF mass-spectrometry-based investigation[J]. Vox Sang,2013,105(2):177-180.
25 Longo V,Marrocco C,Zolla L,et al. Label-free quantitation of phosphopeptide changes in erythrocyte membranes: towards molecular mechanisms underlying deformability alterations in stored red blood cells[J]. Haematologica,2014,99(7):e122-125.
26 Kannan M,Atreya C. Differential profiling of human red blood cells during storage for 52 selected microRNAs[J]. Transfusion,2010,50(7):1581-1588.
27 Silliman C C,Kelher M R,Khan S Y,et al. Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo[J]. Blood,2014,123(22):3488-3495.
28 Dinkla S,Wessels K,Verdurmen W P,et al. Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure[J]. Cell Death Dis,2012,3(10):e410.
29 Dinkla S,Peppelman M,Van Der Raadt J,et al. Phosphatidylserine exposure on stored red blood cells as a parameter for donor-dependent variation in product quality[J]. Blood Transfus,2014,12(2):204-209.
30 Kleinman S,Busch M P,Murphy E L,et al. The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study(REDS-III): a research program striving to improve blood donor and transfusion recipient outcomes[J]. Transfusion,2014,54(3):942-955.
31 vanderMeer P F,Cancelas J A,Cardigan R,et al. Evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell(RBC)additive solutions on in vitro RBC measures[J]. Transfusion,2011,51(1):15S-24S.

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红细胞贮存损伤的生化和组学变化研究进展^*

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