血红蛋白氧亲和力在临床应用的研究进展*

doi:10.3969/j.issn.1671-2587.2019.02.004

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (2): 124-129.DOI: 10.3969/j.issn.1671-2587.2019.02.004

• P₅₀血红蛋白氧亲和力的临床应用专题 • 上一篇下一篇

血红蛋白氧亲和力在临床应用的研究进展^*

褚宗棠, 王瑛, 赵莲, 周虹

100850 北京,中国人民解放军军事科学院军事医学研究院卫生勤务与血液研究所

收稿日期:2018-10-11 出版日期:2019-04-20 发布日期:2019-04-10
通讯作者: 周虹,女,天津市人,研究员,医学博士,主要从事血液代用品、失血性休克及抗休克药物的研究,(Tel) 010-66931982 (Email) zhouhtt1966@163.com
作者简介:褚宗棠（1990-）,男,山东武城人,技师,硕士,主要从事血液代用品研究工作,(Tel) 010-66931970 (Email) m18613105106@163.com
基金资助:
*本课题受国家自然科学基金青年基金（No.81700181,No.81600148）资助

Received:2018-10-11 Online:2019-04-20 Published:2019-04-10

摘要/Abstract

摘要： 人体内氧的运输主要依赖红细胞内血红蛋白与氧的结合和解离,血红蛋白与氧结合的能力即血红蛋白氧亲和力是血红蛋白的重要特征之一。氧亲和力通过血红蛋白氧饱和度为50%时的氧分压（P₅₀）表征。所以,P₅₀反映出人体的氧摄入和组织细胞的氧获取的能力,其改变受多种因素影响,包括体内H⁺浓度、二氧化碳分压（PCO₂）、温度、2,3-二磷酸甘油酸（2,3-DPG）等变构效应剂及多种药物。P₅₀的检测和调节在输血和潜在的疾病诊断及治疗等临床应用方面具有巨大的研究空间和潜力。

中图分类号:

R331.1⁺41

褚宗棠, 王瑛, 赵莲, 周虹. 血红蛋白氧亲和力在临床应用的研究进展^*[J]. 临床输血与检验, 2019, 21(2): 124-129.

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血红蛋白氧亲和力在临床应用的研究进展^*

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