长沙地区无偿献血者输血传播HIV残余风险评估

doi:10.3969/j.issn.1671-2587.2023.04.015

临床输血与检验 ›› 2023, Vol. 25 ›› Issue (4): 509-513.DOI: 10.3969/j.issn.1671-2587.2023.04.015

长沙地区无偿献血者输血传播HIV残余风险评估

胡婷婷, 邹彬彬, 赵飞雪

长沙血液中心,湖南长沙 410026

收稿日期:2023-07-11 出版日期:2023-08-20 发布日期:2023-09-18
通讯作者: 赵飞雪,主要从事输血安全研究与实验室管理工作,（E-mail）173353705@qq.com。
作者简介:胡婷婷,主要从事血液检测与质量控制方面研究,（E-mail）475007092@qq.com。

Assessment of Residual Risk of HIV Transmission among Voluntary Blood Donors in Changsha Area

HU Tingting, ZOU Binbin, ZHAO Feixue

Changsha Blood Center, Hunan 410026

Received:2023-07-11 Online:2023-08-20 Published:2023-09-18

摘要/Abstract

摘要： 目的评估长沙地区2014年1月1日—2022年12月31日无偿献血者输血传播人类免疫缺陷病毒（human immunodeficiency virus,HIV）残余风险。方法通过血站信息管理系统回顾性分析长沙血液中心2014年1月1日—2022年12月31日无偿献血者HIV血液筛查结果与疾病预防控制中心（CDC）反馈的确证结果,采用发病率-窗口期数学模型评估无偿献血者HIV筛查残余风险。结果研究期间长沙地区HIV确证阳性率为0.199 5‰（273/1 368 333）,其中初次献血者757 455例,占比55.36%,确证阳性率0.249 5‰（189/757 455）,重复献血者有610 878例,占比44.64%,确证阳性率0.137 5‰ （84/610 878）,初次及重复献血者两组确证阳性率存在统计学差异（χ²=21.270,P<0.001）。初次献血者HIV残余风险为1/204 081.63高于重复献血者残余风险1/370 370.37。如果只开展HIV血清学检测,窗口期参残余风险为1/85 470,而增加HIV核酸检测血液筛查后,残余风险降低至1/250 000,NAT筛查较血清学筛查能降低65.81%的残余风险。结论长沙地区无偿献血者输血传播HIV残余风险的评估有助于评价不同检测策略对血液安全的影响,保障血液质量。

关键词: 人类免疫缺陷病毒（HIV）, 输血残余风险, 发病率-窗口期模型, 无偿献血者

Abstract: Objective This study is to investigate the residual risk of HIV transmission among blood donors in Changsha city from 2014 to 2022. Methods The blood screening results of unpaid blood donors from January 1, 2014 to December 31, 2022 in Changsha Blood Center and the confirmed results fed back by the Center for Disease Control and Prevention (CDC) were retrospectively analyzed through the blood station information management system, and the residual risk of HIV screening of unpaid blood donors was assessed using the incidence rate window mathematical model. Results During the study period, the HIV positive rate in the Changsha area was 0.199 5 ‰ (273/1 368 333), among first-time blood donors was 757 455 accounting for 55.36%, the HIV positive rate was 0.249 5 ‰ (189/757 455) and the repeat blood donors was 610878 accounting for 44.64%, the HIV positive rate was 0.1375 ‰ (84/610 878). There was a statistical difference in the positive rates between the first and repeat blood donors (χ²=21.270, P<0.001). The residual risk of HIV among first-time blood donors was 1/204 081.63, which is higher than that of repeat blood donors by 1/370 370.37. The residual risk of HIV is 1/85 470 in the two-time enzyme-linked immunosorbent assay (ELISA). After HIV Nucleic acid test (NAT) blood screening, the residual risk was reduced to 1/250 000. NAT screening can reduce the residual risk by 65.81%. Conclusion The assessment of residual risks may help to evaluate the impact of different testing strategies on blood safety and ensure blood quality

Key words: HIV, Residual risk of blood transfusion, Incidence rate-window model, Blood donors

中图分类号:

R457.1⁺2

胡婷婷, 邹彬彬, 赵飞雪. 长沙地区无偿献血者输血传播HIV残余风险评估[J]. 临床输血与检验, 2023, 25(4): 509-513.

HU Tingting, ZOU Binbin, ZHAO Feixue. Assessment of Residual Risk of HIV Transmission among Voluntary Blood Donors in Changsha Area[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(4): 509-513.

参考文献

[1] 王瑞,李玲,刘正敏,等.基于HIV检测结果对反应性献血者分类管理的探讨[J].中国输血杂志,2022,35(3):296-300.
[2] 王宇骁,王涛,王宇航.《献血者健康检查要求》(GB18467-2011)在日常工作中的心得体会[J].中国输血杂志,2012,25(S1):31.
[3] PILLONEL J,PELAT C,TIBERGHIEN P,et al.The evolving blood donor deferral policy for men who have sex with men:impact on the risk of HIV transmission by transfusion in France[J].Transfusion,2020,60(3):525-534.
[4] MAPAKO T,MVERE D A,CHITIYO M E,et al.Human immunodeficiency virus prevalence,incidence,and residual transmission risk in first-time and repeat blood donations in Zimbabwe:implications on blood safety[J].Transfusion,2013,53(10pt2):2413-2421.
[5] 葛文超,吕永磊,陈明军,等.郑州地区无偿献血者血液筛查中丙型肝炎病毒残余风险的评估[J].中国输血杂志,2022,35(5):546-549.
[6] 董杰,祝宏,凌霞,等.杭州地区无偿献血者血液筛查中丙型肝炎病毒残余风险的评估[J].中国现代医生,2020,58(16):144-147.
[7] WANG J X,LIU J,YAO F Z,et al.Prevalence,incidence,a nd residual risks for transfusion-transmitted human immunodeficiency virus Types 1 and 2 infection among Chinese blood donors[J].Transfusion,2013,53(6):1240-1249.
[8] BRUHN R,LELIE N,CUSTER B,et al.Prevalence of human immunodeficiency virus RNA and antibody in first-time,lapsed,and repeat blood donations across five international regions and relative efficacy of alternative screening scenarios[J].Transfusion,2013,53(10pt2):2399-2412.
[9] 冯惟萍,张支凤,吴康乐,等.兰州地区输血传播HIV残余风险规避策略研究[J].中国艾滋病性病,2022,28(2):199-202.
[10] 陕柏峰,史宏睿,焦东丽.太原市血液筛查后输血传播HIV残余风险度的评估[J].中国艾滋病性病,2020,26(5):540-542.
[11] 何子毅,陈庆恺,陈少彬,等.四种血液安全筛查模式对经血传播病毒残余风险的评估[J].中国输血杂志,2018,31(2):140-143.
[12] 张品品,李江,何刚,等.自贡地区无偿献血人群HIV感染情况及人群特征分析[J].中国输血杂志,2018,31(11):1288-1291.
[13] 吴洁,潘安杰,张艳,等.芜湖地区无偿献血者HIV筛查策略及确认结果分析[J].中国输血杂志,2021,34(3):293-296.
[14] GREBE E,BUSCH M P,NOTARI E P,et al.HIV incidence in US first-time blood donors and transfusion risk with a 12-month deferral for men who have sex with men[J].Blood,2020,136(11):1359-1367.
[15] VERMEULEN M,LELIE N,COLEMAN C,et al.Assessment of HIV transfusion transmission risk in South Africa:a 10-year analysis following implementation of individual donation nucleic acid amplification technology testing and donor demographics eligibility changes[J].Transfusion,2019,59(1):267-276.
[16] 冯娟. 安阳地区无偿献血人群HIV输血风险评估[J].中国输血杂志,2016,29(2):171-173.
[17] 段学云,左江涛,焦东丽,等.太原市无偿献血者HIV流行率及血液筛查后残余风险度的评估[J].中国卫生检验杂志,2015,25(3):417-419.
[18] GRUBYTĖ S,URBONIENĖ J,NEDZINSKIENE L,et al.Prevalence,incidence and residual risk of transfusion transmitted viruses (HBV,HCV and HIV infections) in Lithuanian blood donors from 2004 to 2018:the incidence/window-period model study[J].PLoS One,2021,16(2):e246704.
[19] 谢君谋,廖芬芳,王淏,等.2例重复献血者HIV血清学检测窗口期追踪结果分析[J].临床输血与检验,2022,24(5):647-650.
[20] 王静,文赟筠,周春,等.南京市无偿献血者HIV感染状况及防控策略分析[J].临床输血与检验,2018,20(5):485-488.
[21] 张荣秋,张建梅,李莉.HIV-1抗体不确定患者追踪随访及其病毒载量分析[J].中国艾滋病性病,2020,26(6):584-586.
[22] 樊璐. 2012-2019年南昌地区无偿献血者HIV初筛和确证结果分析[J].中国艾滋病性病,2020,26(12):1286-1289.
[23] 李浩,朱阳泉,苗琦.镇江市无偿献血者HIV检测结果回顾性分析[J].实验与检验医学,2021,39(1):233-235.
[24] 戚晓东,臧传邦,宋雪梅.血站酶联免疫检测联合核酸检测降低输血传播疾病残余风险的效果分析[J].中国卫生检验杂志,2016,26(3):373-374.

长沙地区无偿献血者输血传播HIV残余风险评估

Assessment of Residual Risk of HIV Transmission among Voluntary Blood Donors in Changsha Area

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

关于本刊

作者中心

在线期刊

访问统计

联系我们

[1]	张震, 洪俊, 徐钰茜, 钱惠忠, 许友山. 无锡地区无偿献血者ABO亚型血型血清学及分子生物学特征研究[J]. 临床输血与检验, 2021, 23(5): 644-647.
[2]	赵娜娜, 王超, 金惠新, 赵阳, 吕蓉. 合肥地区无偿献血人群CD36抗原缺失的调查^*[J]. 临床输血与检验, 2021, 23(2): 152-155.
[3]	朱红芹, 林红. 献血者红细胞意外抗体检出率、反应强度和特异性分析[J]. 临床输血与检验, 2021, 23(1): 75-78.
[4]	李萌, 赵玉伟, 李莹, 魏习薇, 谭茜茜, 傅雪梅. 无偿献血者健康检查标准的国内外比较^*[J]. 临床输血与检验, 2021, 23(1): 116-122.
[5]	程卫芳, 周学勇, 崔伟娅, 张云, 王凯, 袁亮, 赵璐璐, 吕晴. 单项HBV核酸反应性献血者两次追踪结果分析[J]. 临床输血与检验, 2020, 22(5): 514-517.
[6]	王侠, 吴博, 李美霖, 张剑平. 农牧地区献血人群布鲁氏菌筛查分析^*[J]. 临床输血与检验, 2020, 22(5): 518-521.
[7]	张秀红. 唐山市献血人群弓形虫抗体检测和输血残余风险分析[J]. 临床输血与检验, 2020, 22(2): 138-141.
[8]	杨图深, 夏萍, 于文林, 王艺蓉, 袁秀琴. 佛山市南海区无偿献血者满意度调查分析^*[J]. 临床输血与检验, 2019, 21(4): 401-405.
[9]	林俊填, 刘知华, 何其通, 杨富燕, 余玉婷, 伍伟健. 佛山地区无偿献血人群酶免联合核酸检测结果分析[J]. 临床输血与检验, 2018, 20(6): 569-571.
[10]	刘玉强. 开封市无偿献血者梅毒确认阳性结果的调查分析[J]. 临床输血与检验, 2018, 20(6): 618-620.
[11]	黎世杰, 冯凡凡, 陈锦艳, 梁燕梅, 邓学成, 吴蕾, 蓝琴, 戎霞. 2010~2015年广州地区无偿献血人群HIV感染现状分析^*[J]. 临床输血与检验, 2018, 20(5): 457-462.
[12]	张艳红. 2013~2015年江门市全血献血者脂肪血发生情况分析[J]. 临床输血与检验, 2018, 20(5): 467-469.
[13]	李莉华, 戚海, 陈莉, 马印图. 石家庄地区无偿献血者HTLV-Ⅰ/Ⅱ检测情况分析[J]. 临床输血与检验, 2018, 20(5): 482-486.
[14]	王静, 文赟筠, 周春, 朱绍汶, 蒋昵真. 南京市无偿献血者HIV感染状况及防控策略分析[J]. 临床输血与检验, 2018, 20(5): 485-488.
[15]	刘红梅,路志浩. 阜阳市2014~2016年无偿献血者梅毒检测结果分析[J]. 临床输血与检验, 2018, 20(3): 259-260.