自体单采富血小板血浆在脱发治疗中的临床应用专家共识*

doi:10.3969/j.issn.1671-2587.2024.01.001

临床输血与检验 ›› 2024, Vol. 26 ›› Issue (1): 1-7.DOI: 10.3969/j.issn.1671-2587.2024.01.001

• 专家共识 • 下一篇

自体单采富血小板血浆在脱发治疗中的临床应用专家共识^*

中国生物医学工程学会血液疗法与工程分会, 中国整形美容协会毛发医学分会, 富血小板血浆创新技术脱发治疗项目组

收稿日期:2024-02-03 发布日期:2024-03-13
通讯作者: 吴文育,教授,主任医师,博导,主要从事毛发疾病的诊断及治疗等研究,（E-mail） wenyu_wu@fudan.edu.cn。共同通信作者：夏荣,教授,主任医师,博导,主要从事血液治疗及输血相关免疫调节研究,（E-mail） rongxia@fudan.edu.cn。共同通信作者：宫济武,主任技师,主要从事输血管理、免疫血液学、临床输血等研究,（E-mail）13910066259@139.com。共同通信作者：单桂秋,主任医师,主要从事临床输血及血小板拓展应用方面的研究,（E-mail）rabbit_2007@126.com。
作者简介:夏荣（复旦大学附属华山医院输血科）,吴文育（复旦大学附属华山医院皮肤科）,王苑（复旦大学附属华山医院输血科）,盛友渔（复旦大学附属华山医院皮肤科）
基金资助:
*本课题受国家自然科学基金面上项目（No.82070197）,上海市重中之重研究中心建设项目（No.2023ZZ02018）,上海市卫生健康领军人才项目（No.2022LJ017）,上海申康医院发展中心项目（No.SHDC22022302）,国家重点研发计划（No.2023YFC2509001）,上海毛发医学工程技术研究中心项目（No.19DZ2250500）资助

Received:2024-02-03 Published:2024-03-13

摘要/Abstract

摘要： 脱发是临床常见疾病,严重影响患者的心理健康和生活质量,如能及早诊治可明显延缓脱发进程,提高患者生活质量。富血小板血浆（PRP）治疗对于某些类型的脱发,特别是雄激素性秃发（AGA）已被证实疗效肯定,为传统方法治疗效果不理想的患者提供了新的治疗选择。但由于PRP制备技术、储存方法及头皮注射等治疗方案差异较大, PRP治疗脱发的疗效报道不一。本共识由国内多家具有自体单采PRP制备、保存及脱发治疗丰富经验的三甲医院的输血科、皮肤科、整形外科等专家,在充分总结PRP治疗脱发临床实践经验的基础上,结合国际、国内PRP治疗相关文献,全面、系统回顾性分析了自体单采PRP应用于脱发治疗的临床经验,并进行了深入探讨后达成本共识。共识内容包含7个方面:背景、PRP治疗脱发的机制、适应证和禁忌证、PRP的制备与保存、治疗方法及效果评价、不良反应及处理、结语。推荐：采用血细胞分离机单采血小板技术制备自体PRP,PRP中血小板浓度在1 000×10⁹/L~1 500×10⁹/L、红细胞混入浓度≤3.2×10¹⁰/L,贫白细胞PRP（LP-PRP）治疗脱发效果最佳;非激活PRP（A-PRP）和激活PRP（AA-PRP）均可以治疗脱发,更推荐在脱发治疗中使用A-PRP;PRP的使用首推新鲜采集的PRP治疗,亦可一次采集、分装后于-80℃~-70℃冷冻保存,存储时间不超过3个月;1个疗程注射3次~6次,每次间隔2周~4周,注射部位为真皮深层及皮下,本共识有助于提高PRP治疗脱发的效果及其评价的科学性,为今后制定规范的自体单采PRP治疗脱发指南或/和标准奠定基础。

关键词: 自体富血小板血浆, 单采, 脱发, 治疗, 专家共识

中图分类号:

R331.1⁺43

中国生物医学工程学会血液疗法与工程分会, 中国整形美容协会毛发医学分会, 富血小板血浆创新技术脱发治疗项目组. 自体单采富血小板血浆在脱发治疗中的临床应用专家共识^*[J]. 临床输血与检验, 2024, 26(1): 1-7.

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