输血（医学）科基于离心分离技术建立单采/血液净化治疗体系的探索

doi:10.3969/j.issn.1671-2587.2024.06.001

临床输血与检验 ›› 2024, Vol. 26 ›› Issue (6): 721-725.DOI: 10.3969/j.issn.1671-2587.2024.06.001

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输血（医学）科基于离心分离技术建立单采/血液净化治疗体系的探索

庄远, 于洋

解放军总医院第一医学中心输血医学科,北京 100853

收稿日期:2024-07-08 出版日期:2024-12-20 发布日期:2024-12-20
通讯作者: 于洋,主要从事单采治疗、野战输血及智能化输血辅助决策系统研究,（E-mail）yuyangpla301@163.com。
作者简介:庄远,主要从事临床单采治疗和研究,（E-mail）zhuangyuan0215@126.com。

Strengthening the Application of Centrifugal Technology and Establishing a Combined Apheresis/Blood Purification System in the Department of Transfusion Medicine

ZHUANG Yuan, YU Yang

Department of Blood Transfusion, First Medical Center of Chinese PLA General Hospital, Beijing 100853

Received:2024-07-08 Online:2024-12-20 Published:2024-12-20

摘要/Abstract

摘要： 非输血血液疗法（Non-transfusional hemotherapy, NTH）的主要承担者应为输血（医学）科,而血细胞离心分离技术是承担此类治疗的技术基础。血浆分离可有两种技术方式实现：离心式和膜滤过式,而两者的技术各有特点。以血细胞离心分离技术为基础的单采治疗/血液净化显示了血浆分离效率高、治疗用时短、血小板损耗低、红细胞不易破坏及使用枸橼酸抗凝利于重症患者非持续性临床治疗的优势。适合输血（医学）科离心技术使用的二级柱可以实现免疫吸附、人工肝支持系统、离心-膜滤过血浆置换及炎性因子吸附等治疗,从而以越来越精细的血浆二级处理技术实现传统血浆置换的有益补充。

关键词: 非输血的血液疗法, 免疫吸附, 人工肝支持系统, 离心-膜滤过血浆置换

Abstract: Non-transfusional hemotherapy should be mainly carried out by the Transfusion Department, which basis is the apheresis technology by centrifugation. The plasmapheresis can be realized in two ways: centrifugal and membrane filtration, each of which has its own technical characteristics. Apheresis/blood purification based on centrifugation shows the advantages of higher plasma separation efficiency, shorter treatment time, less platelet loss, less destruction of red blood cells, and the use of citrate anticoagulation for non-continuous clinical treatment of critically ill patients. Secondary columns suitable for centrifugal technology can realize immunoadsorption, artificial liver support system, centrifugation-filtration plasmapheresis and inflammatory factor adsorption. Using increasingly sophisticated secondary column technology should be a useful supplement to traditional TPE.

Key words: Non-transfusional hemotherapy, Immunoadsorption, Artificial liver support system, Centrifugation-filtration plasmapheresis

中图分类号:

R457

庄远, 于洋. 输血（医学）科基于离心分离技术建立单采/血液净化治疗体系的探索[J]. 临床输血与检验, 2024, 26(6): 721-725.

ZHUANG Yuan, YU Yang. Strengthening the Application of Centrifugal Technology and Establishing a Combined Apheresis/Blood Purification System in the Department of Transfusion Medicine[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(6): 721-725.

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输血（医学）科基于离心分离技术建立单采/血液净化治疗体系的探索

Strengthening the Application of Centrifugal Technology and Establishing a Combined Apheresis/Blood Purification System in the Department of Transfusion Medicine

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