冷冻储存对血小板结构和功能影响的研究进展*

doi:10.3969/j.issn.1671-2587.2025.05.017

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (5): 695-700.DOI: 10.3969/j.issn.1671-2587.2025.05.017

冷冻储存对血小板结构和功能影响的研究进展^*

李娇, 李剑平, 李晓丰

辽宁省血液中心辽宁省输血医学研究所,辽宁沈阳 110063

收稿日期:2025-09-02 修回日期:2025-09-11 出版日期:2025-10-20 发布日期:2025-10-11
通讯作者: 李晓丰,主要从事输血医学研究,（E-mail）cathleen_lxf@126.com。共同通信作者：李剑平,主要从事输血医学研究,（E-mail）ljp_63@163.com。
作者简介:李娇,主要从事输血医学研究,（E-mail）jiaoli0311@126.com。
基金资助:
^*本课题受沈阳市科技创新平台建设计划项目（No.21-104-0-15）、沈阳市科学技术计划（No.24-214-3-122）资助

Research Progress on the Effect of Cryopreservation on Platelets Structure and Function

LI Jiao, LI Jianping, LI Xiaofeng

Liaoning Provincial Blood Center Liaoning Transfusion Medicine Institute, Shenyang 110044

Received:2025-09-02 Revised:2025-09-11 Online:2025-10-20 Published:2025-10-11

摘要/Abstract

摘要： 血小板功能和生存能力的维持直接影响临床疗效。然而,冷冻储存对血小板的影响仍然是一个亟待深入研究的领域。血小板的冷冻储存研究已有近70年历史,冷冻储存包括冷冻方法的选择、冷冻剂以及储存时间的长短等都会对血小板的基础特征和功能指标产生影响。尽管冷冻储存技术为血小板的长期储存提供了可能,但在临床应用中仍面临多项挑战,如冷冻血小板的解冻后功能恢复及其在输血中的有效性等问题。本文通过综述近年来的相关研究进展,旨在为改善血小板冷冻储存技术提供理论基础和实践指导,以期提升血小板的临床使用效果。

关键词: 血小板, 冷冻储存, 功能

Abstract: The maintenance of platelet function and viability directly impacts clinical outcomes, yet the effects of cryopreservation on platelets remain a critical area requiring further investigation. With over 70 years of research history, cryopreservation protocols—including selection of freezing methods, cryoprotectants, and storage duration—significantly influence platelet characteristics and functional parameters. While cryopreservation technology enables long-term storage, clinical applications still face challenges such as restoring thawed platelet function and ensuring effective transfusion outcomes. This review synthesizes recent advancements to provide theoretical foundations and practical guidance for optimizing platelet cryopreservation techniques, ultimately enhancing clinical efficacy in platelet utilization.

Key words: Platelet, Cryopreservation, Function

中图分类号:

R457

李娇, 李剑平, 李晓丰. 冷冻储存对血小板结构和功能影响的研究进展^*[J]. 临床输血与检验, 2025, 27(5): 695-700.

LI Jiao, LI Jianping, LI Xiaofeng. Research Progress on the Effect of Cryopreservation on Platelets Structure and Function[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 695-700.

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冷冻储存对血小板结构和功能影响的研究进展^*

Research Progress on the Effect of Cryopreservation on Platelets Structure and Function

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