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临床输血与检验

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (2): 169-172.DOI: 10.3969/j.issn.1671-2587.2019.02.016

• 临床检验 • 上一篇    下一篇

低血红蛋白密度联合红细胞体积分布宽度在儿童小细胞低色素性贫血诊断中的价值

王金生, 邹伟洋, 黄光墉, 刘晓鸽, 刘典浪, 林侠   

  1. 518103 广东省深圳市宝安区福永人民医院检验科
  • 收稿日期:2018-08-17 出版日期:2019-04-20 发布日期:2019-04-10
  • 作者简介:王金生（1982-）,男,广东深圳人,主管技师,学士,主要从事临床和生化免疫工作,（Tel）13925210651。

The Significance of Low Hemoglobin Density Combined with RBC Volume Distribution Width for Diagnosis of Small Cell Hypochromic Anemia of Children

WANG Jin-sheng, ZOU Wei-yang, HUANG Guang-yong, et al   

  1. Clinical Laboratory of Shenzhen Fuyong Hospital of Bao-an,Guangdong 518103
  • Received:2018-08-17 Online:2019-04-20 Published:2019-04-10

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摘要： 目的 探讨低血红蛋白密度（1ow haemoglobin density,LHD）联合红细胞体积分布宽度（red blood cell volume distribution width,RDW）在儿童小细胞低色素性贫血（microcytic hypochromic anemia,MHA）患者诊疗中的价值。方法 收集2016年7月~2017年8月深圳市宝安区福永人民医院确诊为小细胞低色素性贫血患者102例为研究组,收集同期健康儿童120例为对照组,运用Sysmex XN9000全自动血球分析仪分别检测研究组治疗前、治疗3个月后和对照组血常规,根据血常规参数中的红细胞平均血红蛋白浓度（MCHC）计算出LHD,并对LHD和RDW结果进行统计分析。结果 对照组外周血中LHD值为2.97%±0.93%,其中男性为3.25%±1.03%,女性为2.49%±0.78%,男性高于女性,差异有统计学意义（t=4.029,P<0.05）,RDW值为12.01%±2.56%,其中男性为11.93%±2.46%,女性为12.30%±2.72%,女性略高于男性,但差异无统计学意义（t=0.917,P>0.05）。治疗前,研究组外周血中LHD和RDW值分别为32.57%±18.62%和17.06%±3.54%,明显高于对照组,差异有统计学意义（t=4.287~21.052,P<0.05~0.01）。治疗后,LHD和RDW值分别为11.32%±9.74%和13.85%±2.73%,明显低于治疗前,差异有统计学意义（t=3.571~10.187,P<0.05）,但治疗前后不同性别患者之间差异均无统计学意义（t=0.592~1.095,P>0.05）。LHD和RDW浓度随着MHA患儿贫血程度加重而增加。结论 小细胞低色素性贫血患者治疗前外周血中LHD和RDW值明显升高,而治疗后明显降低。且治疗前有性别差异,治疗后则没有差异。因此,LHD和RDW值对小细胞低色素性贫血患者诊疗的动态监测和疗效考核具有一定参考价值。

关键词: 低血红蛋白密度, 红细胞体积分布宽度, 小细胞低色素性贫血, 价值

Abstract: Objective To investigate the value of low hemoglobin density （LHD） combined with red blood cell volume distribution width （RDW） for the diagnosis and treatment of microcytic hypochromic anemia （MHA） in child patients. Method One hundred and two patients with MHA were collected and 120 healthy children were taken as the control. Blood routine tests of the all samples were performed with Sysmex XN9000 Cell Analyzer before and 3 months after treatments. LHD was obtained based on average hemoglobin concentration （MCHC） and both LHD and RDW were statistically analyzed. Results The values of LHD （32.57%±18.62%）and RDW （17.06%±3.54%） in the patients before treatments were found to be obviously higher than those in the control（LHD：2.97%±0.93%; and RDW：12.01%±2.56%） （t=4.287~21.052,P<0.05~0.01）. The high LHD value was mostly noted in males but not females（t=4.029,P<0.05）. LHD and RDW values after treatments,however,were 11.32%±9.74% and 13.85%±2.73%,respectively,which was notably lower than those before treatments（t=3.571~10.187,P<0.05）. No statistical difference was seen in gender （t=0.592~1.095,P>0.05）. Additionally,the concentration of both LHD and RDW increased with the severity of anemia . Conclusion The values of LHD and RDW in the patients with MHA increased with the severity of the disease but significantly decreased following treatments,suggesting their significance in monitoring of MHA.

Key words: Low hemoglobin density, Volume distribution of RBC, Microcytic hypochromic anemia, Value

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