Abstract: ObjectiveTo investigate the CLIA and TP-ELISA for detection of antibody against syphilis. Methods4 7 6 cases of PubMed,VIP,WangFang and CNKI database were searched out, and analyzed by RevMan 4 .2 . Results11 articles reported a total of 2 5 4 1 3 patients. Tests for heterogeneity χ2= 2.05 , df=10（P>0.05）showed the relative risk of the combined result [OR=1.01 ,95% CI（0.93 ,1.09）, P>0.05] and 9 5% CI horizontal and vertical study line（on behalf of RR=1） intersect. It was found that the difference of CLIA and TP-ELISA for detection of antibodies to syphilis was not statistically significant. ConclusionsELISA and CLIA methods are clinically useful and reliable for screening of Treponema pallidum infection before surgery or blood transfusion.

Key words: CLIA, TP-ELISA, Meta, analysis