Abstract: Objective To investigate the fresh frozen plasma （FFP）VIII derived from the whole blood with CPDA or ACD-B blood preservative solution,content difference and analyze the relative factors. Methods 48 cases of FVIII derived from the whole blood with CPDA （A group） or ACD-B （B group） blood preservative solution were randomized for the determination respectively,compared the two groups of the mean value and qualified rate of FVIII. Results There was no significant difference between the 2 groups of FVIII content （P>0.05）,compared with the A group,the qualified rate of FVIII quality standards in B group decreased significantly. Conclusion The decline of qualified rate of FVIII quality standards in B group related to the related factors such as the decrease of the concentration of dilution caused by the increase of the liquid storage capacity,the actual blood collection and so on.

Key words: Blood preservative solution, Blood volume, FⅧ