Abstract: Objective To investigate the clinical value of serum 5'-NT, TBA combined with MAO in the diagnosis of liver tumors. Methods 250 patients with liver disease treated in our hospital from May 2014 to May 2016 were selected as the observation group. The patients were divided into three groups according to the type of disease：liver tumor group, chronic hepatitis group, cirrhosis group, severe hepatitis group, acute hepatitis group and type Hepatitis group; and then select the same period to our hospital for physical examination of 100 cases as a control group. Serum levels of 5'-NT, TBA, MAO, AST, ALT and GGT were detected in each group and compared with each other.Results The levels of TBA, AST, ALT and GGT in 250 patients were significantly higher than those in the control group （P<0.05）.The levels of serum 5'-NT in liver tumor group, chronic hepatitis group, cirrhosis group, acute hepatitis group and hepatitis C group were higher than those in control group, the difference was statistically significant （P<0.05）.There was no significant difference in serum 5'-NT level between the severe hepatitis group and the control group （P>0.05）.The levels of MAO in liver tumor group and cirrhosis group were significantly higher than those in control group （P<0.05）.There was no significant difference in MAO level between the other groups and the control group （P>0.05）.The levels of serum 5'-NT in chronic hepatitis group, cirrhosis group, severe hepatitis group, acute hepatitis group and hepatitis C group were lower than those in liver tumor group （P<0.05）.The level of TBA in severe hepatitis group was higher than that in liver tumor group, acute hepatitis group and hepatitis C group, the difference was statistically significant （P<0.05）.The levels of MAO in chronic hepatitis group, severe hepatitis group, acute hepatitis group and hepatitis C group were lower than those in liver tumor group （P<0.05）.The levels of ALT in chronic hepatitis group, severe hepatitis group and acute hepatitis group were higher than those in liver tumor group （P<0.05）.The levels of GGT in liver cirrhosis group, severe hepatitis group, acute hepatitis group and hepatitis C group were lower than those in liver tumor group, the difference was statistically significant （P <0.05）.Conclusions erum 5'-NT, TBA combined with MAO detection in the diagnosis of liver tumors in patients with liver secretion, synthesis and metabolic function has a high sensitivity, serum 5'-NT, TBA, MAO, AST, ALT and GGT levels can be effective Response to the degree of liver function damage, for the differential diagnosis of liver disease to provide a reliable basis.

Key words: Serum 5'-NT, TBA, MAO, Diagnosis, Liver tumor, Clinical value