Abstract: Objective To explore the diagnostic value of IL-17/NF-kBp65 signaling pathway related factors in patients with acute cerebral hemorrhage on early prognosis and its sate of illness. Methods The vein blood of eighty-nine acute cerebral hemorrhage patients （cerebral hemorrhage group）and sixty healthy person （control group）was collected,the levels of serum interleukin-17,nucler factor kB p65,interleukin-6,interleukin-8 were detected by enzyme-linked immunosorbent assay,the relationship between different mount of blood,different illness,prognosis and indexes mentioned above was analysed. The diagnostic value of IL-17,NF-kB p65,IL-6,IL-8 on prognosis and illness was performed by Receiver Operating Characteristic. Results Compared to the control group,the serum levels of IL-17,NF-kB p65,IL-6,IL-8 in the cerebral hemorrhage group were obviously increased,the difference between groups was statistically significant （P﹤0.01）. The serum levels of IL-17,NF-kB p65,IL-6,IL-8 in the large amount group and mild mount hemorrhage group were markly higher than in the small mount group,while those indexes in the large amount group were markly higher than in the mild mount group （P﹤0.05）. The serum levels of IL-17,NF-kB p65,IL-6,IL-8 in the severe group and moderate group were markly higher than in the mild group,while those indexes in the severe group were markly higher than in the moderate group （P﹤0.05）. The serum levels of IL-17,NF-kB p65,IL-6,IL-8 in the deterioration group were markedly higher than that in the non-deterioration group,the difference between groups was statistically significant （P﹤0.05）. The serum IL-17,NF-kB p65,IL-6,IL-8 in the patients had its clinical prediction significance to the prognosis and illness of patients. Conclusion There are correlation between illness sate of progression and level of IL-17,NF-kB p65,IL-6,IL-8,which can be used as indexes for illness and prognosis of acute cerebral hemorrhage.

Key words: Interleukin-17, Nucler fctror kB p65, Interleukin-6, Interleukin-8, Acute cerebral hemorrhage, Diagnosis