Abstract: Objective To explore the method and feasibility of returning reactive blood donors and seek the balance between blood loss and blood safety. Method sScreening of previous blood donors who meet the conditions for returning to the site to re-collect specimens (Screening of always eligible for this site back to collect blood donors specimens) (time interval ≥6 months ). Routine ELISA and NAT detection first,if there is no reactivity,the blood will be sent to the provincial blood bank for confirmation experiments and supplementary experiments.(makes the province blood center and added Confirmatory tests). Results From January 2014 to April 2008,a total of 166 recalled blood donors were selected,of which 63 specimens were unqualified in routine testing,and unqualified items were the same as previous screening items.(Dating from January 2014 to April 2018,a total of 166 cases of recalled blood donors were recalled,among which 63 cases of samples failed the routine test of this site,and the unqualified items were the same as the previous shielding items.) 103 cases of non-reactive specimens which detected by ELISA and NAT were sent to the provincial blood center. 83 of them were confirmed to be negative and could return to the team. (All 103 cases of ELISA test and NAT test were sent to the provincial blood center without reactive samples,of which 83 cases were confirmed negative and could be returned to the team. ) 31of the 83 people donated blood again and 13 of them donated blood several times. (In 83 case,31 cases were again donate blood and 13 cases were donated multiple times.) ConclusionAt present,the ELISA test and the NAT test combined with the confirmatory test could ensure blood safety to a large extent.(the combination of ELISA test and NAT test with confirmatory test ensures the safety of blood to a large extent. )This makes it possible for some of the fake reaction donors,especially the gray area and the weakly positive fake blood donors,to return to the blood donor team again,(It also enables some blood donors with false-reactive,especially those in grey zone and weak positive ones,to return to the blood donor team again,)which is of great significance for promoting the development of voluntary blood donation.

Key words: Reactive, blood, donors, False-, reactive, Donor, reentry, Confirmatory, test