Abstract: Objective The factors of deferred blood donation between whole blood donors and aphaeresis donors in some blood collection and supply institutions from 2019 to 2021 were compared and analyzed. Methods A retrospective analysis method was used to collect data related to deferred donors in some blood collection and supply institutions from 2019 to 2021, which were divided into A and B groups according to provincial (blood centers) and prefecture-level (central blood stations). Blood donors were divided into whole blood donors and aphaeresis donors. The main studies were alcohol consumption, drug use, menstrual period, past medical history, underweight, abnormal body temperature, abnormal pulse, abnormal blood pressure, chylous blood, abnormal hemoglobin (Hb), elevated alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg) positive, hepatitis C antibody (anti-HCV) positive, syphilis serum specific antibody (anti -TP) positive, HIV antibody (anti-HIV) positive, and other 16 reasons for deferred blood donation. According to different groups, blood donors and the ranking of deferred blood donation reasons, relevant data of deferred blood donation rate and deferred blood donation reasons ranked first, second and third were collected respectively for comparative analysis. Results The deferred blood donation rate of whole blood donors (median 8.57%) was lower than that of aphaeresis donors (median 10.79%). The median deferred blood donation rate of different blood donors in different years in group A was higher than that in group B, and there were significant differences between them. Among the top 3 reasons for deferred blood donation reported, whole blood donors involved 11 reasons, more than the aphaeresis donors drinking alcohol, taking drugs, abnormal pulse 3 reasons; ALT elevation, chylous blood and Hb abnormality have been reported for a total of 194 (74.33%) times in whole blood donors and 187 (71.65%) times in aphaeresis donors, which are the most important reasons for deferred blood donation. Conclusion There are differences in deferred blood donation factors between whole blood donors and aphaeresis donors in some blood collection and supply institutions.

Key words: Blood donation deferral, Blood safety, Donor screening, Donor selection