Abstract: As a new technology of compatibility detection of blood transfusion，electronic blood cross matching has been used in some developed countries for many years，and the feasibility and safety of applications related have also been studied in recent years. In this paper，through the brief understanding of the research of the electronic cross matching technology，the security problems of the domestic technology of the application are expounded. Even if some domestic hospitals already have met conditions to carry out electronic matching，but because of the lack of standards，some key technologies to be further standardized and clear，still can not guarantee that the new technology in the safety of clinical application，it attracted enough attention. Electronic identification，such as the identity of the two patients，the blood type antibody screening reagent red blood cell antigen spectrum of the design and construction of transfusion quality management information system，access system，required to be strictly regulated，suitable for clinical application of domestic electronic matching technology standard，can guarantee the safety of this technology in clinical application.

Key words: Electronic cross-matching , Blood group identification, Cross matching , Antibody screening , Blood safety