Abstract: Objective To evaluate the efficacy and safety of different dose of platelets in pediatric patients with acute lymphoblastic leukemia. Methods It was a retrospective analysis of 483 platelet transfusions in 56 pediatric patients with acute lymphoblastic leukemia. All cases were divided into three groups according to the actual infusion dose per unit body surface area. Low dose group：<2.2×10¹¹/m²,middle dose group：2.2~4.4×10¹¹/m²,high dose group：>4.4×10¹¹/m². The 24-h platelet count increase index（CCI）was calculated and adverse reaction events were recorded during transfusion. We compared the efficacy between different transfusion doses,and analyzed the CCI values in the effective infusion cases. Results There were no significant differences for the effective rate of platelet transfusion and adverse reaction rate among the three groups. In the effective transfusion cases,there was no statistical difference in CCI values between the groups,but in PPI values,there was statistical difference. Conclusion In children with acute lymphocytic leukemia,the platelet infusion dose is not a major influencing factor of the efficacy. And the high-dose platelet infusion does not improve the platelet count increase index. The 0.5 therapeutic dose of platelets are feasible in pediatric application.

Key words: Platelet transfusion, Transfusion dose, Acute lymphoblastic leukemia, Pediatric