血浆PCT、CRP水平检测指导呼吸道感染患儿抗生素使用的临床价值

doi:10.3969/j.issn.1671-2587.2018.05.023

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (5): 528-531.DOI: 10.3969/j.issn.1671-2587.2018.05.023

血浆PCT、CRP水平检测指导呼吸道感染患儿抗生素使用的临床价值

罗平

618000 四川省绵竹市人民医院

收稿日期:2018-02-25 出版日期:2018-10-20 发布日期:2018-09-27
作者简介:罗平（1964-）,女,四川德阳人,学士,主要从事儿科工作,（Tel）0838-6202297（E-mail）luoping818924@163.com。

Clinical Value of PCT- and CRP-Oriented Antibiotics Application to Children with Respiratory Tract Infection

LUO Ping

People's Hospital of Mianzhu City,Sichuan Province,Mianzhu 618000

Received:2018-02-25 Online:2018-10-20 Published:2018-09-27

摘要/Abstract

摘要： 目的分析血浆降钙素原（PCT）及C-反应蛋白（CRP）水平检测在指导呼吸道感染患儿合理使用抗生素中的应用价值,为临床治疗提供依据。方法选取本院2013年8月~2016年2月收治的呼吸道感染患儿248例,采用随机数字法分为对照组和观察组,每组各124例,对照组患儿行常规标准检查+CRP水平检测指导治疗,观察组在此基础上增加PCT水平检测指导治疗,比较两组患儿治疗后临床症状消失时间、抗生素使用时间、住院时间;同时比较两组患儿抗生素使用率、二重感染率及病情加重率。结果 ①治疗后观察组患儿发热、咳嗽、肺部干湿性啰音症状消失时间与对照组患儿比较,差异无统计学意义（P>0.05）;②观察组患儿抗生素使用时间、住院时间均短于对照组,差异有统计学意义（P<0.05）;③治疗后观察组抗生素使用率明显低于对照组,差异有统计学意义（P<0.05）。结论常规标准检查及CRP水平检测联合PCT水平检测指导呼吸道感染患儿抗生素用药,能明显减少抗生素的使用时间、使用率及治疗后二重感染发生率,同时缩短患儿住院时间,提高治疗效果,为呼吸道感染患儿的合理抗生素治疗提供依据,值得临床大力推广。

关键词: 降钙素原, 抗生素, 二重感染

Abstract: Objective To observe the clinical value of the plasma procalcitonin （PCT） and C-reactive protein （CRP） in guidance of the rational antibiotic treatment in children with respiratory tract infection. Methods A total of 248 cases of respiratory tract infections were selected in the hospital from August 2013 to February 2016. The patients were randomly divided into control group and observation group,with 124 cases in each. The control group was given antibiotic treatments monitored by CRP testing,while the observation group received the treatments supervised by both CRP and PCT tests. Results No significant difference was seen of the duration of fever,cough and lung rales between the two groups （P>0.05）. However,the durations of antibiotic use and hospital stay were obviously shortened in the observation group than in the control （P<0.05） with a notably decreased frequency of antibiotic uses （P<0.05）. Conclusion Combination of CRP with PCT test may help reduce the frequency and duration of antibiotic uses and avoid double-infection of post-treatment through monitoring the efficacy of the drugs in the children with pulmonary infections .

Key words: Procalcitonin, Antibiotic, Respiratory tract infection

中图分类号:

R446.11R969.3

罗平. 血浆PCT、CRP水平检测指导呼吸道感染患儿抗生素使用的临床价值[J]. 临床输血与检验, 2018, 20(5): 528-531.

LUO Ping. Clinical Value of PCT- and CRP-Oriented Antibiotics Application to Children with Respiratory Tract Infection[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2018, 20(5): 528-531.

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血浆PCT、CRP水平检测指导呼吸道感染患儿抗生素使用的临床价值

Clinical Value of PCT- and CRP-Oriented Antibiotics Application to Children with Respiratory Tract Infection

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