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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (5): 521-524.DOI: 10.3969/j.issn.1671-2587.2018.05.021

• 临床检验 • 上一篇    下一篇

联合检测PCT、FDP、CRP在儿童脓毒血症中的临床价值

余艳丽, 汪建军, 王军阳   

  1. 712000 咸阳,西安交通大学医学部基础医学院病原生物学与免疫学系（余艳丽,王军阳）;
    陕西省核工业二一五医院输血科（余艳丽,汪建军）
  • 收稿日期:2018-03-15 出版日期:2018-10-20 发布日期:2018-09-27
  • 通讯作者: 王军阳,男,主要从事抗感染免疫研究工作,（E-mail）xajdyxywjy@163.com。
  • 作者简介:余艳丽（1980-）,女,陕西咸阳人,主管技师,学士,主要从事临床生化、输血管理工作,（E-mail）3142322401@qq.com。

Clinical Significance of the Combined Detection of Procalcitonin,Fibrin and Fibrinogen Degradation Products and C-reactive Protein in Children with Sepsis

YU Yan-Li, WANG Jian-Jun, WANG Jun-Yang   

  1. Department of Blood Transfusion,Nuclear Industry No.215 Hospital of Shanxi and Department of Pathogenic Biology and Immunology,Medical college of Xi'an Jiaotong University,Xianyang,Shanxi Province 712000
  • Received:2018-03-15 Online:2018-10-20 Published:2018-09-27

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摘要： 目的 探讨降钙素原（procalcitonin,PCT）、纤维蛋白（原）降解产物（fibrin and fibrinogen degradation products,FDP）、C-反应蛋白（C-reactive protein,CRP）联合检测在儿童脓毒血症中的临床应用价值。方法 选取2015年5月~2016年6月在本院儿科、ICU住院的33例脓毒血症患者,一般感染者35例为观察组,另随机抽取健康体检儿童35例为对照组,分别采用双抗体夹心免疫化学发光法、免疫比浊法检测血清PCT、FDP、CRP水平。结果 脓毒血症组PCT、FDP、CRP明显高于一般感染组和正常对照组,差异具有统计学意义（P<0.05）,一般感染组CRP与正常对照组的差异有统计学意义（P<0.05）,PCT、FDP的差异无统计学意义（P>0.05）,脓毒血症组随着急诊脓毒症死亡风险（mortality in emergency department sepsis,MEDS）评分的增加,PCT、FDP、CRP水平增高（P<0.05）。结论 血清PCT、FDP、CRP是感染的重要指标,联合检测有助于更加准确的预测儿童脓毒血症的病情进展,具有很好的临床应用价值。

关键词: 降钙素原, 纤维蛋白（原）降解产物, C-反应蛋白, 脓毒血症

Abstract: Objective To investigate the value of clinical applications of the combined detection of procalcitonin（PCT）,fibrin and fibrinogen degradation products（PDP）and C-reactive protein（CRP）in junior patients with sepsis. Methods Samples were collected from 33 patients with sepsis,and 35 common infectious patients in pediatrics and intense care unit（ICU）. Thirty five healthy children were chosen as the control. All specimens were harvested from March 2015 to June 2016. PCT was measured by double-antibody sandwich chemiluminescence immunoassay,FDP and CRP were measured by immunoturbidimetry,respectively. Results The levels of PCT,FDP and CRP in sepsis group were obviously higher than those in common infectious group and the control group,the differences were statistically significant（P<0.05）. CRP level was higher in common infectious group（P<0.05）,no difference was noted of PCT and FDP（P>0.05）. Moreover,with the risk of mortality in emergency department sepsis （MEDS）increase,the levels of all items tested were elevated（P<0.05）. Conclusion PCT,FDP and CRP are important markers during infection. A combined detection of the three markers has a great value in predicting the disease progression in children sepsis.

Key words: Procalcitonin, Fibrin and fibrinogen degradation products, C-reactive protein, Sepsis

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