肾移植术后肺孢子菌肺炎患者外周血降钙素原及CRP的变化

doi:10.3969/j.issn.1671-2587.2019.04.025

临床输血与检验 ›› 2019, Vol. 21 ›› Issue (4): 424-427.DOI: 10.3969/j.issn.1671-2587.2019.04.025

肾移植术后肺孢子菌肺炎患者外周血降钙素原及CRP的变化

冯思涵, 徐晓玲

230001 中国科学技术大学附属第一医院呼吸科

收稿日期:2019-03-12 出版日期:2019-08-20 发布日期:2019-08-28
通讯作者: 徐晓玲,女,教授,主任医师,硕士生导师,（E-mail）xxlahh08@163.com。
作者简介:冯思涵（1992-）,男,安徽黄山人,住院医师,研究生,主要从事肾移植术后PCP患者相关指标变化方面研究,（Tel）15395072522（E-mail）598632603@qq.com。

Variation of Procalcitonin and CRP in Peripheral Blood of Patients with Pneumocystis Pneumonia After Renal Transplantation

FENG Si-han, XU Xiao-ling

Anhui Provincial Hospital,230001

Received:2019-03-12 Online:2019-08-20 Published:2019-08-28

摘要/Abstract

摘要： 目的探究早期检测血浆降钙素原及CRP在肾移植后肺孢子菌肺炎（PCP）患者中的变化以及对与细菌性肺炎进行鉴别诊断的价值。方法采用前瞻性临床观察研究对我院55例肾移植术后PCP的患者在入院后立刻进行外周血降钙素原与CRP检验,根据诊断方式分为移植术后肺孢子菌肺炎确诊组、肺孢子菌肺炎临床诊断组,对收集的数据采取适合的统计学方法进行描述并进行比较。结果 55例PCP患者总体血浆降钙素原浓度较正常水平未出现明显变化,55例患者中有51例降钙素原位于正常值范围,占总体92.7%。CRP浓度较正常值轻度升高,55例患者中有47例CRP轻度升高,占比87.5%。其中临床诊断组患者血浆降钙素原与CRP水平均高于确诊组,但是这一差异无统计学意义（P>0.05）。结论肾移植术后PCP患者降钙素原较正常人无明显变化,但CRP水平轻度升高,这可能对同细菌性肺炎的鉴别并无价值。

关键词: 肾移植, 肺孢子菌感染, 降钙素原, C反应蛋白

Abstract: Objective To investigate the changes of plasma procalcitonin and C-reactive protein (CRP) in patients with Pneumocystis pneumonia(PCP) following renal transplantation and to study the value of differential diagnosis of Pneumocystis and bacterial pneumonia. Methods Fifty-five patients with PCP after renal transplantation in the hospital were examined for procalcitonin and CRP by prospective clinical observation. The patients were divided into two groups according to the diagnosis methods, and the patients with PCP after transplantation were divided into two groups: group of definitive diagnosis (group A) and group of clinically suspected diagnosis(group B). The patients of group B were described and compared with the data collected by appropriate statistical methods. Results The serum procalcitonin concentration in 55 patients with PCP remained unchanged. The CRP concentration in 47 of the 55(87.5%) patients showed a slight increase. The serum levels of procalcitonin and CRP in group B were found to be slightly higher than those in group A but no significant difference was noted (P>0 05). Conclusion Procalcitonin and CRP concentrations remains unchanged significantly in PCP patients after renal transplantation, both can not be used for differential diagnosis of Pneumocystis or bacteria pneumonia.

Key words: Kidney transplant, Pneumocystis infection, Procalcitonin, CRP

中图分类号:

R446.11

冯思涵, 徐晓玲. 肾移植术后肺孢子菌肺炎患者外周血降钙素原及CRP的变化[J]. 临床输血与检验, 2019, 21(4): 424-427.

FENG Si-han, XU Xiao-ling. Variation of Procalcitonin and CRP in Peripheral Blood of Patients with Pneumocystis Pneumonia After Renal Transplantation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2019, 21(4): 424-427.

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肾移植术后肺孢子菌肺炎患者外周血降钙素原及CRP的变化

Variation of Procalcitonin and CRP in Peripheral Blood of Patients with Pneumocystis Pneumonia After Renal Transplantation

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