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临床输血与检验

临床输血与检验 ›› 2020, Vol. 22 ›› Issue (3): 316-318.DOI: 10.3969/j.issn.1671-2587.2020.03.023

• 临床检验 • 上一篇    下一篇

丙肝病毒核心抗原检测的临床价值及其与HCV-RNA、ALT、AST的关系研究

刘英超, 张秋月, 刘琳, 任更朴   

  1. 252600 聊城市第二人民医院,山东第一医科大学附属聊城二院检验科
  • 收稿日期:2019-01-22 出版日期:2020-06-20 发布日期:2020-06-13
  • 通讯作者: 任更朴,男,主任技师,学士,主要从事临床免疫和生物化学检验,（E-mail）lceylyc@163.com。
  • 作者简介:刘英超（1985-）,男,山东临清人,主治医师,硕士,主要从事临床免疫与分子生物学检验,（Tel）15275667636（E-mail）yingchao621@163.com。

Clinical Value of HCV-cAg Detection and Its Relationship with HCV-RNA, ALT and AST

LIU Ying-chao, ZHANG Qiu-yue, LIU Lin, et al   

  1. Department of Clinical Laboratory, The Second People's Hospital of Liaocheng, Liaocheng, The Second Hospital of Liaocheng affiliated to Shandong First Medical University,Shandong 252600
  • Received:2019-01-22 Online:2020-06-20 Published:2020-06-13

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摘要： 目的 探讨丙肝病毒核心抗原（HCV-cAg）检测的临床价值及其与HCV-RNA、ALT、AST的关系。方法 留取112例HCV-cAg检测阳性标本,205例丙肝病毒核心抗体（HCV-Ab）阳性标本,利用实时定量PCR法测定HCV-RNA,同时进行肝功能（ALT、AST）检测。结果 112例HCV-cAg阳性和205例HCV-Ab阳性标本中,HCV-RNA阳性分别为95例（阳性率84.8%）和142例（阳性率69.3%）,前者显著高于后者（P<0.05）;前者肝功能异常70例（占62.5%）,后者肝功能异常95例（占46.3%）,前者显著高于后者（P<0.05）。HCV-cAg结果S/CO值增高与HCV-RNA 阳性率和肝功能异常率呈正相关。结论 HCV-cAg检测阳性结果与HCV-RNA符合率高,并能够反应肝功能损伤程度,HCV-cAg检测对辅助临床诊疗具有重要的价值。

关键词: 丙型肝炎, 丙肝病毒核心抗原, 丙肝病毒核心抗体, 丙肝病毒RNA, 肝功能

Abstract: Objective To investigate the clinical value of detection of HCV-cAg and its relationship with HCV-RNA, ALT and AST. Methods 112 HCV-cAg positive specimens and 205 HCV-Ab positive specimens were collected. Real-time Quantitative PCR method was used to detect HCV-RNA , and at the same time liver function (ALT, AST) was detected. Results There were 95 HCV-RNA-positive cases from the 112 HCV-cAg positive specimens ( a positive rate of 84.8%) and 142 HCV-RNA-positive cases from 205 HCV-Ab positive specimens (a positive rate of 69.3%), respectively, and therewas significantly higher HCV RNA positive rate in the former than that in the latter (P<0.05); The former had 70 cases of abnormal liver function (62.5%) and the latter 95 cases (46.3%). The former was significantly higher than that of the latter (P<0.05).The increase of the value of S/CO in HCV-cAg results was positively correlated with the positive rate of HCV-RNA and the abnormal rate of liver function. Conclusion The positive results of HCV-cAg test highly correlate to HCV-RNA, and reflect the status of liver function. HCV-Ag test has important value in assisted clinical diagnosis.

Key words: Hepatitis C, Hepatitis C virus core antigen, Hepatitis C virus core antibody, Hepatitis C virus RNA, Liver function

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