富血小板血浆与间充质干细胞的联合应用在再生医学中的前景*

doi:10.3969/j.issn.1671-2587.2024.03.020

临床输血与检验 ›› 2024, Vol. 26 ›› Issue (3): 420-426.DOI: 10.3969/j.issn.1671-2587.2024.03.020

富血小板血浆与间充质干细胞的联合应用在再生医学中的前景^*

赵子悦, 黄韦华, 查占山

海军军医大学第一附属医院输血科,上海 200433

收稿日期:2024-02-08 出版日期:2024-06-20 发布日期:2024-06-24
通讯作者: 查占山,主要从事血液免疫研究工作,（E-mail）chazhanshan@163.com。
作者简介:赵子悦,主要从事血液免疫工作,（E-mail）zzy695782289@163.com。
基金资助:
*海军军医大学第一附属医院固海计划项目（No.GH-145-37）、国家自然科学基金（青年科学基金项目No.82200257）资助

The Prospect of Combined Application of Platelet-rich Plasma and Mesenchymal Stem Cells in Regenerative Medicine

ZHAO Ziyue, HUANG Weihua, CHA Zhanshan

Department of Blood Transfusion, Changhai Hospital, The First Affiliated Hospital of PLA Naval Medical University 200433

Received:2024-02-08 Online:2024-06-20 Published:2024-06-24

摘要/Abstract

摘要： 富血小板血浆（PRP）与间充质干细胞（MSCs）的联合应用在再生医学中展现出巨大的潜力,为治疗各种疾病和组织再生提供了新的治疗策略和有力工具。该联合应用结合了PRP中丰富的生长因子和MSCs的多向分化潜能,产生协同作用,有助于加速组织再生和修复过程。在不同医学领域,如整形美容、骨科、心血管和不孕症治疗等,PRP与MSCs的联合应用展现出广泛的应用潜力。此外,个体化医疗也得以实现,根据患者的特定情况调整治疗方案,提高治疗效果。然而,联合应用也存在一些风险和限制。其中不受控制分化、出血和血栓等风险需要特别注意。此外,长期安全性、效果的持续性以及治疗方案的标准化仍然存在不确定性,需要更多的大规模研究来验证。综上所述,PRP与MSCs的联合应用为再生医学领域带来了新的希望和前景,但在应用时需要谨慎权衡其优势与风险,以确保治疗方案的安全性和有效性。

关键词: 富血小板血浆, 间充质干细胞, 再生医学

Abstract: The combined application of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) has shown great potential in regenerative medicine, providing new therapeutic strategies and powerful tools for the treatment of various diseases and tissue regeneration. This combined application combines the abundant growth factors in PRP and the multidirectional differentiation potential of MSCs to produce a synergistic effect that accelerate tissue regeneration and repair processes. The combined application of PRP and MSCs in different medical fields, such as orthopedics, orthopedics, cardiovascular and infertility treatment, has shown a wide range of application potential. In addition, personalized medicine has been made possible to adjust the treatment plan according to the specific situation of the patient and improve the treatment effect. However, there are some risks and limitations in the process. Among them, the risks of uncontrolled differentiation, bleeding and thrombosis require to be payed specialattention. In addition, the long-term safety, persistence of effects, and standardization of treatment protocols remain uncertain and need to be verified by more large-scale studies. In summary, the combined application of PRP and MSCs brings new hope and prospects for the field of regenerative medicine, but the advantages and risks need to be carefully weighed to ensure the safety and effectiveness of treatment options.

Key words: Platelet-rich plasma, Mesenchymal stem cells, Regenerative medicine

中图分类号:

R457.1

赵子悦, 黄韦华, 查占山. 富血小板血浆与间充质干细胞的联合应用在再生医学中的前景^*[J]. 临床输血与检验, 2024, 26(3): 420-426.

ZHAO Ziyue, HUANG Weihua, CHA Zhanshan. The Prospect of Combined Application of Platelet-rich Plasma and Mesenchymal Stem Cells in Regenerative Medicine[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2024, 26(3): 420-426.

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富血小板血浆与间充质干细胞的联合应用在再生医学中的前景^*

The Prospect of Combined Application of Platelet-rich Plasma and Mesenchymal Stem Cells in Regenerative Medicine

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