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临床输血与检验

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (6): 637-640.DOI: 10.3969/j.issn.1671-2587.2018.06.026

• 临床检验 • 上一篇    下一篇

ERβ2、ERα46在甲状腺乳头状癌的表达及意义

蒲刚   

  1. 636150 四川省宣汉县人民医院
  • 收稿日期:2018-03-22 出版日期:2018-12-20 发布日期:2018-11-12
  • 作者简介:蒲刚（1979-）,男,四川宣汉人,主治医师,学士,主要从事头颈部肿瘤基础与临床研究,（Tel）13908248582。

The Expression and Significance of ER beta 2 and ER Alpha 46 in Papillary Thyroid Carcinoma

PU Gang   

  1. Department of Otorhinolaryngology Head and Neck Surgery,Xuanhan People's Hospital,Sichuan 636150
  • Received:2018-03-22 Online:2018-12-20 Published:2018-11-12

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摘要： 目的 分析ERβ2、ERα46在甲状腺乳头状癌（PTC）的表达状态、临床价值及意义。方法 选择手术完整切除的甲状腺乳头状癌40份、正常甲状腺组织40份、结节性甲状腺肿40份。采用免疫组织化学技术（Immunohistochemistry,IHC）检测组织中ERβ2、ERα46表达情况,收集PTC患者术前淋巴结转移情况、临床分期及5年生存率。结果 ERβ2、ERα46在甲状腺乳头状癌阳性表达率分别为92.5%、70.0%,2种受体在甲状腺乳头状癌和良性病变中的阳性表达差异均有统计学意义（P<0.05）。ERβ2、ERα46诊断乳头状癌的灵敏度分别为92.5%、70.0%,特异度分别为72.5%、78.8%;ERβ2、ERα46的表达与甲状腺乳头状癌的临床分期及淋巴结转移有关,差异均有统计学意义（P<0.05）,5年生存率、死亡患者ERβ2、ERα46阳性细胞率的差异无统计学意义（P>0.05）。结论 ERβ2、ERα46在甲状腺乳头状癌中表达增强,在病理诊断中有一定的价值,但对于判断远期预后的情况不明显。

关键词: 雌激素受体, 甲状腺乳头状癌, 临床病理特征, ERβ, 2, ERα, 46

Abstract: Objective To investigate the expression,clinical value and significance of ER beta 2 and ER alpha 46 in papillary thyroid carcinoma （PTC）. Methods The 40 cases of papillary thyroid carcinoma,40 normal thyroid tissues and 40 nodular goiter,were selected. Immunohistochemical technique （Immunohistochemistry,IHC） was used to detect the expression of ER beta 2 and ER alpha 46 in tissue,and the preoperative lymph node metastasis,clinical stage and 5 year survival rate of PTC patients were collected. Results The positive expression rates of ER beta 2 and ER 46 in papillary thyroid carcinoma were 92.5% and 70% respectively,and the positive expression of 2 kinds of receptors in papillary thyroid carcinoma and benign lesion were statistically significant（P<0.05）.The sensitivity of ER beta 2 ER alpha 46,the diagnosis of papillary carcinoma were 92.5% and 70.0% respectively,the specificity was 72.5% and 78.8%; ER beta 2,ER alpha 46 expression with papillary thyroid carcinoma clinical stage and lymph node metastasis,the differences were statistically significant（P<0.05）,and the 5 year survival and death patients that ER beta 2 and ER alpha 46 positive cell rate difference were no statistical significance（P>0.05）. Conclusion The expression of ER beta 2 and ER alpha 46 is increased in papillary thyroid carcinoma,and has some value in pathological diagnosis,but it is not obvious for judging the long-term prognosis.

Key words: Estrogen receptor, Papillary thyroid carcinoma, Clinicopathological features, Er beta 2, ER alpha 46

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