伽马射线辐照对血小板贮存损伤的影响*

doi:10.3969/j.issn.1671-2587.2021.04.028

临床输血与检验 ›› 2021, Vol. 23 ›› Issue (4): 535-540.DOI: 10.3969/j.issn.1671-2587.2021.04.028

伽马射线辐照对血小板贮存损伤的影响^*

刘奇, 王世春, 姚春艳

400038 陆军军医大学第一附属医院输血科

收稿日期:2021-03-31 出版日期:2021-08-20 发布日期:2021-08-18
通讯作者: 姚春艳,女,教授,主任医师,博士,博士研究生导师,主要从事血液安全与临床输血研究,（E-mail）yaochunyan@tmmu.edu.cn。
作者简介:刘奇（1992-）,男,助理实验师,学士,主要从事血液制备及保存研究,（E-mail）403578448@qq.com。
基金资助:
*本课题受国家自然科学基金（No.81700180）资助

Received:2021-03-31 Online:2021-08-20 Published:2021-08-18

摘要/Abstract

摘要： 血液辐照是一种可靠、有效且安全的淋巴细胞灭活技术,常被用来预防输血相关的移植物抗宿主病（TA-GVHD）。研究发现伽马射线辐照对保存过程中血小板的理化性质和凝血功能影响较小,但随着保存时间延长可能会影响血小板的线粒体功能,破坏氧化还原平衡,加速血小板蛋白活化,降低血小板的输注疗效。因此对于伽马射线辐照血小板后,对血小板的产品质量、安全性和有效性的问题值得进一步研究。本文就目前伽马射线辐照后对血小板贮存损伤的影响作一综述。

关键词: 血液辐照, 贮存损伤, 血小板, 血液安全, 伽马射线

中图分类号:

R331.14

刘奇, 王世春, 姚春艳. 伽马射线辐照对血小板贮存损伤的影响^*[J]. 临床输血与检验, 2021, 23(4): 535-540.

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