富血小板血浆修复子宫内膜损伤机制的研究进展*

doi:10.3969/j.issn.1671-2587.2025.02.015

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (2): 247-253.DOI: 10.3969/j.issn.1671-2587.2025.02.015

富血小板血浆修复子宫内膜损伤机制的研究进展^*

刘晓一, 史鸣昊, 李峣, 赵丽艳

吉林大学第二医院输血科,吉林长春 130041

收稿日期:2024-12-04 出版日期:2025-04-20 发布日期:2025-04-17
通讯作者: 赵丽艳,主要从事肿瘤细胞遗传学研究、肿瘤合并血栓分子标志物分析、PRP临床应用的基础研究等,（E-mail）zhaoliy@jlu.edu.cn。
作者简介:刘晓一,主要从事富血小板血浆治疗的基础机制研究,（E-mail）1553082513@qq.com。
基金资助:
*本课题受吉林省科技厅科技发展计划项目（No.20240601004RC)资助

Research Progress on the Mechanism of Endometrial Injury Repair by Platelet-rich Plasma

LIU Xiaoyi, SHI Minghao, LI Yao, ZHAO Liyan

Department of Blood Transfusion, the Second Hospital of Jilin University, Jilin Changchun 130041

Received:2024-12-04 Online:2025-04-20 Published:2025-04-17

摘要/Abstract

摘要： 富血小板血浆（platelet-rich plasma, PRP）是一种血小板浓缩物,激活后可释放多种生长因子,在促进组织修复中发挥着重要作用。目前PRP治疗作为一种新型技术在很多疾病治疗和预后方面已取得显著临床效果,被应用于骨科、疼痛科、皮肤科等多个学科,近几年PRP在生殖医学中的应用受到广泛关注。本文简要综述宫内灌注PRP对子宫内膜损伤修复作用的可能机制,为应用PRP治疗女性不孕症提供理论依据。

关键词: 富血小板血浆, 子宫内膜, 生殖医学

Abstract: Platelet-rich plasma (PRP) is a platelet concentrate that releases various growth factors upon activation and plays an important role in promoting tissue repair. Currently PRP therapy, as a novel technique, has achieved significant clinical results in the treatment and prognosis of many diseases, and has been applied in multiple disciplines such as orthopedics, pain management, and dermatology. In recent years, the application of PRP in reproductive medicine has attracted widespread attention. This article briefly reviews the possible mechanisms of the effect of intrauterine infusion of PRP on endometrial injury repair, providing a theoretical basis for the application of PRP in the treatment of female infertility.

Key words: Platelet-rich plasma, Endometrium, Reproductive medicine

中图分类号:

R711.6R318.08

刘晓一, 史鸣昊, 李峣, 赵丽艳. 富血小板血浆修复子宫内膜损伤机制的研究进展^*[J]. 临床输血与检验, 2025, 27(2): 247-253.

LIU Xiaoyi, SHI Minghao, LI Yao, ZHAO Liyan. Research Progress on the Mechanism of Endometrial Injury Repair by Platelet-rich Plasma[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(2): 247-253.

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富血小板血浆修复子宫内膜损伤机制的研究进展^*

Research Progress on the Mechanism of Endometrial Injury Repair by Platelet-rich Plasma

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