血液及其衍生物在抗衰老疗法中的研究进展与临床应用*

doi:10.3969/j.issn.1671-2587.2025.05.010

临床输血与检验 ›› 2025, Vol. 27 ›› Issue (5): 649-654.DOI: 10.3969/j.issn.1671-2587.2025.05.010

血液及其衍生物在抗衰老疗法中的研究进展与临床应用^*

陈梦柯, 夏荣

复旦大学附属华山医院输血科,上海 200040

收稿日期:2025-08-31 修回日期:2025-09-09 出版日期:2025-10-20 发布日期:2025-10-11
通讯作者: 夏荣,主要从事输血相关免疫调节研究,（E-mail）rongxia@fudan.edu.cn。
作者简介:陈梦柯,主要从事血液相关免疫炎症机制研究,（E-mail）24111220011@m.fudan.edu.cn。
基金资助:
^*本课题受国家自然科学基金面上项目（No.82370232）资助

Blood-derived Products in Anti-aging Therapy: Research Advances and Clinical Translation

CHEN Mengke, XIA Rong

Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai 200040

Received:2025-08-31 Revised:2025-09-09 Online:2025-10-20 Published:2025-10-11

摘要/Abstract

摘要： 衰老是一种多因素驱动的系统性功能退化过程,是癌症、糖尿病、心血管疾病及神经退行性疾病等众多慢性疾病的主要危险因素。近年来,血液及其衍生物作为潜在的抗衰老疗法的使用而备受关注。研究表明,年轻血液成分中的生长因子、细胞因子及小分子代谢物具有显著的组织修复和抗衰老效果,可促进神经发生、增强细胞再生、调节代谢稳态,从而改善老年个体的健康状态。年轻血浆已被发现可逆转神经系统衰退、改善心血管功能、减少肝纤维化、增强肾功能,并在其他多种器官中表现出抗衰老潜力。目前,年轻血浆的临床试验集中于阿尔茨海默病、帕金森病等神经退行性疾病领域,并已在小规模试验中展现出安全性和良好的耐受性。然而,该疗法的长期疗效及安全性仍待验证,且伦理与资源问题需谨慎考量。本文综述了血液及其衍生物在抗衰老疗法中的研究进展,重点探讨其在神经、心血管、肝、肾等系统/器官的恢复作用,并总结了相关临床试验成果,以期为其在抗衰老领域的进一步临床应用提供参考。

关键词: 衰老, 血液制品, 研究进展, 临床应用

Abstract: Aging is a multifactorial, system-wide process of functional decline and is a major risk factor for various chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. In recent years, the use of blood and blood-derived products as potential anti-aging therapies has attracted considerable attention. Studies suggest that growth factors, cytokines, and small-molecule metabolites in young blood components exhibit significant tissue repair and anti-aging effects, promoting neurogenesis, enhancing cellular regeneration, and regulating metabolic homeostasis, thereby improving health in older individuals. Young plasma has been found to reverse neurological decline, improve cardiovascular function, reduce liver fibrosis, and enhance kidney function, showing anti-aging potential across various organs. Current clinical trials of young plasma focus on neurodegenerative diseases such as Alzheimer's and Parkinson's, demonstrating safety and good tolerance in small-scale studies. However, the long-term efficacy and safety of this therapy remain to be validated, and ethical and resource considerations require careful evaluation. This review summarizes research progress on blood and blood-derived products as anti-aging therapies, with a focus on their regenerative effects on the nervous, cardiovascular, hepatic, and renal systems/organs, and consolidates findings from related clinical trials to support further clinical applications in anti-aging interventions.

Key words: Aging, Blood-derived products, Research progress, Clinical applications

中图分类号:

R457.1

陈梦柯, 夏荣. 血液及其衍生物在抗衰老疗法中的研究进展与临床应用^*[J]. 临床输血与检验, 2025, 27(5): 649-654.

CHEN Mengke, XIA Rong. Blood-derived Products in Anti-aging Therapy: Research Advances and Clinical Translation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2025, 27(5): 649-654.

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血液及其衍生物在抗衰老疗法中的研究进展与临床应用^*

Blood-derived Products in Anti-aging Therapy: Research Advances and Clinical Translation

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