Effect of Abscisic Acid on the Generation of Megakaryocytes and Platelets from Induced Pluripotent Stem Cells in vitro Differentiation

doi:10.3969/j.issn.1671-2587.2023.03.024

JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE ›› 2023, Vol. 25 ›› Issue (3): 420-424.DOI: 10.3969/j.issn.1671-2587.2023.03.024

Previous Articles Next Articles

Effect of Abscisic Acid on the Generation of Megakaryocytes and Platelets from Induced Pluripotent Stem Cells in vitro Differentiation

GU Haihui, YUE Wei, YANG Yue, et al

Department of Transfusion Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai 200433

Received:2023-04-18 Published:2023-07-10

Abstract

Abstract: Abscisic acid is a plant hormone, which can inhibit plant growth, promote fruit ripening and defoliation. ABA can affect nucleoside synthesis during animal embryo development, and play an important role in inhibiting tumor cell proliferation, by means of inducing differentiation and apoptosis. Studies have shown that ABA stimulates the production of megakaryocyte and platelet differentiation from human induced pluripotent stem cells in vitro. ABA can affect the number of hematopoietic stem cells, hematopoietic progenitor cells, megakaryocytes and platelets generation from hiPSCs in vitro system. The study on the related effect and underlying mechanism of ABA on megakaryocyte and platelet differentiation from human induced pluripotent stem cells in vitro is of great significance for the production of platelets by large-scale to meet the needs of platelet transfusion in clinical especially for platelet transfusion refractoriness.

Key words: Abscisic acid, Induced pluripotent stem cells, Differentiation, Megakaryocytes, Platelet, in vitro

CLC Number:

R965

GU Haihui, YUE Wei, YANG Yue, et al. Effect of Abscisic Acid on the Generation of Megakaryocytes and Platelets from Induced Pluripotent Stem Cells in vitro Differentiation[J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(3): 420-424.

References

[1] STUBBS J R,HOMER M J,SILVERMAN T,et al.The Current state of the platelet supply in the US and proposed options to decrease the risk of critical shortages[J].Transfusion,2021,61(1):303-312.
[2] IZADY E,SALTANATPOUR Z,LIU L P,et al.Toward in vitro production of platelet from induced pluripotent stem cells[J].Stem Cell Rev Rep,2022,18(7):2376-2387.
[3] LI W Q,WANG L,SHENG X L,et al.Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13[J].Cell Res,2013,23(12):1369-1379.
[4] SCARFÌ S,FERRARIS C,FRUSCIONE F,et al.Cyclic ADP-ribose-mediated expansion and stimulation of human mesenchymal stem cells by the plant hormone abscisic acid[J].Stem Cells,2008,26(11):2855-2864.
[5] BRUZZONE S,MORESCHI I,USAI C,et al.Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger[J].Proc Natl Acad Sci U S A,2007,104(14):5759-5764.
[6] SCARFÌ S,FRESIA C,FERRARIS C,et al.The plant hormone abscisic acid stimulates the proliferation of human hemopoietic progenitors through the second messenger cyclic ADP-ribose[J].Stem Cells,2009,27(10):2469-2477.
[7] ZOCCHI E,CARPANETO A,CERRANO C,et al.The temperature-signaling cascade in sponges involves a heat-gated cation channel,abscisic acid,and cyclic ADP-ribose[J].Proc Natl Acad Sci USA,2001,98(26):14859-14864.
[8] NAGAMUNE K,HICKS L M,FUX B,et al.Abscisic acid controls calcium-dependent egress and development in Toxoplasma gondii[J].Nature,2008,451(7175):207-210.
[9] 罗云清,陈凯,侯力群,等.脱落酸抗肥胖作用研究[J].吉林农业大学学报,2016,38(1):69-73.
[10] SPINELLI S,BEGANI G,GUIDA L,et al.LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway[J].Mol Metab,2021,53:101263.
[11] 韩佳彤,丁传波,顾效瑜,等.脱落酸对果糖诱导的胰岛素抵抗小鼠的影响[J].食品科学,2015,36(15):195-198.
[12] MAGNONE M,BRUZZONE S,GUIDA L,et al.Abscisic acid released by human monocytes activates monocytes and vascular smooth muscle cell responses involved in atherogenesis[J].J Biol Chem,2009,284(26):17808-17818.
[13] 钟骏桥,向俊峰,尹航,等.脱落酸对人胰腺癌细胞增殖的影响[J].中华实验外科杂志,2013,30(1):17-19.
[14] 朱迪,陈冉,孙岩,等.植物激素在临床中的应用[J].广西医学,2019,41(9):1156-1159.
[15] MAGNONE M,STURLA L,GUIDA L,et al.Abscisic acid:a conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome[J].Nutrients,2020,12(6):1724.
[16] MALARA A,FRESIA C,DI BUDUO C A,et al.The plant hormone abscisic acid is a prosurvival factor in human and murine megakaryocytes[J].J Biol Chem,2017,292(8):3239-3251.
[17] Alan D.Michelson等著.阮长耿,朱力,戴克胜等主译.血小板[M].第4版.北京:人民卫生出版社,2022:42-43
[18] SUGIMOTO N,KANDA J Y,NAKAMURA S,et al.iPLAT1:the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study[J].Blood,2022,140(22):2398-2402.
[19] CHEN S J,SUGIMOTO N,ETO K.Ex vivo manufacturi ng of platelets:beyond the first-in-human clinical trial using autologous iPSC-platelets[J].Int J Hematol,2023,117(3):349-355.
[20] HUANG W H,GU H H,ZHAN Z Y,et al.The plant hormone abscisic acid stimulates megakaryocyte differentiation from human iPSCs in vitro[J].Platelets,2022,33(3):462-470.

Effect of Abscisic Acid on the Generation of Megakaryocytes and Platelets from Induced Pluripotent Stem Cells in vitro Differentiation

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

About

Author

Journal

Access Statistics

Contact

[1]	ZHANG Wenjuan, DUAN Yong, JI Yuqiang, et al. LncRNA SNHG9 in Apheresis Platelets Following Storage [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(3): 310-315.
[2]	ZHANG Qiang, YUE Xianhu, LI Rui, et al. Platelet-rich Plasma as a Treatment for Lateral Patellar Compression Syndrome [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(3): 348-353.
[3]	LIU Qin, SHEN Xiantao, XU Chunfen, et al. Efficacy of Autologous Platelet-rich Plasma in Pathologic Fracture Healing in Children [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(3): 354-357.
[4]	GONG Mimi, WANG Haining, WU lei, et al. Efficacy of Allogeneic Platelet Rich Plasma for Chronic Refractory Wounds [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(3): 368-374.
[5]	WANG Qiao-gai, BI Li-bo, LIU Su-rui. Platelet Rich Fibrin Releasate Improves Atopic Dermatitis in Rats: an Experimental Study [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(1): 69-74.
[6]	LI Jie, ZHANG Xue-rui, CHEN Zhong-ru, et al. Correction Effect of Platelets Preserved with Qingkailing Injections in Vitro Model of Massive Blood Loss [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(1): 88-96.
[7]	ZHANG Yu, YE Sheng, RUI Xue, et al. Establishment of HLA and HPA Gene Database of Regular Platelet Donors in Nanjing Area [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(1): 127-132.
[8]	LI Wan, WANG Ya, XIAO Guang-lin, et al. Research Progress in the Relationship of Apheresis Donation to Bone Metabolism and Bone Mineral Density [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2023, 25(1): 143-148.
[9]	QING Yun, ZHOU Qiong, PENG Kai, et al. Performances of Platelet Storage in SSP+ Additive Solution versus Plasma [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(6): 698-704.
[10]	MAO Ping-ping, WANG Shu-jun, LUO Kai-yun, et al. Study on the Antibacterial Effect of Frozen Platelet-rich Plasma and Lyophilized Platelet-rich Plasma [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(6): 705-709.
[11]	WEI Yan, LIU Kuan, LI Xiang-jun, et al. Observation on the Therapeutic Effect of PRP in the Treatment of Traumatic Synovitis of Ankle Joint [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(6): 725-729.
[12]	YAO Dan, DING Hong-juan, YU Wei, et al. A Multivariate Prediction Model of Platelet Transfusion in Patients with Severe Postpartum Hemorrhage [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(6): 743-748.
[13]	SONG Ying-wei, BIAN Cheng-rong, PAN Xue, et al. The Effect of Multiple Platelet Donation on some Parameters of the Blood Routine in Male Apheresis Platelet Donors [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(5): 610-614.
[14]	NIU Si-ying, XU Jia-jie, XU Meng-yao, et al. Development of Improved Parallel Plate Flow Chamber and Its Application in the Measurement of Platelet Adhesion Under Pathological Vascular Conditions [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(3): 308-314.
[15]	WANG Jing, HU Yan, ZHU Man, et al. Preliminary Study on Spermine Tetrahydrochloride Inhibition of Platelet Activation [J]. JOURNAL OF CLINICAL TRANSFUSION AND LABORATORY MEDICINE, 2022, 24(3): 315-319.