• 中国科学论文统计源期刊
  • 中国科技核心期刊
  • 美国化学文摘(CA)来源期刊
  • 日本科学技术振兴机构数据库(JST)

临床输血与检验 ›› 2018, Vol. 20 ›› Issue (1): 79-82.DOI: 10.3969/j.issn.1671-2587.2018.01.027

• 临床检验 • 上一篇    下一篇

NLR、PLR、RDW在感染性休克诊断、监测及预后评估中的应用*

陈伟, 刘艳, 刘金菊, 戴小辉, 肖小红, 肖扬   

  1. 417000 湖南省娄底市中心医院(陈伟,刘金菊,戴小辉,肖小红,肖扬), 湖南省娄底市妇幼保健院/儿童医院(刘艳)
  • 收稿日期:2017-06-30 出版日期:2018-02-20 发布日期:2018-02-28
  • 通讯作者: 肖扬,男,主要从事骨科临床工作,(E-mail)xiao_yang168@sina.com。
  • 作者简介:陈伟(1983-),男,湖南湘潭人,主管检验师,硕士,主要从事分子免疫和感染免疫工作,(Tel)15576356510。
  • 基金资助:
    *本课题受中央引导地方科技发展专项(No.2017CT5028)、娄底市科技创新计划项目(No.LDKJ201706)资助

Clinical Application of NLR,PLR and RDW to Diagnosis,Monitoring and Prognosis of Septic Shock

CHEN Wei, TAN Hua-qing, LIU Jin-ju, et al   

  1. Loudi Center Hospital of Hunan,Hunan Loudi,417000
  • Received:2017-06-30 Online:2018-02-20 Published:2018-02-28

摘要: 目的 研究中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)及红细胞分布宽度(RDW),在感染性休克的诊断、动态监测及预后评估中的临床意义。方法 选择感染性休克患者155例(其中死亡组76例、治愈组79例),同期以健康体检人群155例作为阴性对照组。比较病例组与对照组在降钙素原(procalcitonin,PCT)、WBC、RDW、PLR及NLR之间的差异,分析各指标对感染性休克的诊断效率及其与PCT的相关性。比较死亡组与治愈组之间的差异,分析各指标与患者结局的相关性。结果 PCT、WBC、RDW、PLR、NLR在病例组与对照组比较差异均有统计学意义,NLR以4.68为诊断临界值,诊断灵敏度和特异度分别为96.1% 和95.5%。PLR以14.62为诊断临界值,诊断灵敏度和特异度分别为72.3% 和66.4%。PCT与NLR、PLR呈正相关(r=0.884,0.599)。感染性休克病例组中死亡率为49.03%,死亡组与治愈组比较PCT、RDW有差异。患者结局与PCT、RDW呈负相关(r=-0.165,-0.449)。不同时间段患者的PCT、WBC、PLR、NLR有差异,且PCT与NLR、PLR在不同时间段有明显相关性。结论 NLR、PLR与PCT呈明显正相关,可用于辅助诊断及动态监测感染性休克患者,RDW与患者结局呈明显负相关,对患者预后评估有一定的临床意义。

关键词: 感染性休克, 降钙素原, 中性粒细胞/淋巴细胞比值, 血小板/淋巴细胞比值, 红细胞分布宽度

Abstract: Objective To study clinical significance of NLR,PLR and RDW in the diagnosis,dynamic monitoring and prognosis of septic shock. Methods One hundred and fifty-five cases of septic shock(group death:76 deaths,cured group:79 cases)and 155 cases of healthy control were subjected to NLR,PLR and RDW blood testing. A comparison was made in PCT,WBC,RDW,PLR and NLR for their efficiency in diagnosis of septic shock. Results PCT,WBC,RDW,PLR and NLR tests in cases group revealed a statistical significance. The diagnostic sensitivity and specificity were 96.1% and 95.5%,respectively when 4.68 was taken as NLR diagnosis threshold,and 72.3% and 66.4%,respectively when 14.62 was used as PLR threshold. PCT had significantly positive correlation with NLR and PLR(r=0.884,0.599). The mortality of septic shock was 49.03%. A difference was seen between PCT and RDW in deaths and cured individuals. Patient outcome had positive correlation with PCT and RDW(r=-0.165,-0.449).Conclusion NLR and PLR had positive correlation with PCT,that can be used to for diagnosis and dynamic monitoring in septic shock patients due to their convenience,economy,and easy application.

Key words: Septic shock, Procalcitonin, Neutroplhil to lymphocyte ratio, Platelet to lymphocyte ratio, Red blood cell distribution width

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